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Boc-Beta-Alanine (Boc-β-Ala-OH) is a protected β-amino acid derivative (CAS: 3303-84-2), featuring a Boc-protected amine and a free carboxylic acid group. It appears as a white crystalline powder (MW: 189.21 g/mol).
Uses:
Peptide synthesis — standard building block in solution-phase and solid-phase (Boc-SPPS) peptide assembly
PROTAC linker — used in proteolysis-targeting chimera drug development
Medicinal chemistry — building block for novel therapeutics and bioactive compounds
L-Carnosine synthesis — precursor for this antioxidant dipeptide
Energy supplements — amino acid derivative for performance-enhancing formulations
Selling points:
Achiral — no racemization risk, simplifying synthesis and purification
Clean deprotection — Boc removal via TFA yields only gaseous byproducts (CO₂, isobutylene), leaving no residue
Dual reactivity — orthogonal protected amine + free carboxyl enables precise sequential coupling
High purity (≥98%) and excellent stability for routine lab use
Versatile platform serving peptide, drug discovery, and supplement markets
Specifications of Boc-beta-alanine CAS 3303-84-2 COA:
Items | Specifications | Results |
Appearance | White or off-white powder | White powder |
Water Content | ≤1.0% | 0.05% |
Melting point | 72℃~79℃ | 73.4℃~76.7℃ |
Content | 98.0%~102.0% | 98.57% |
Purity | ≥98.0% | 98.66% |
Conclusion | The product conforms to the above specifications. | |
CAS:3303-84-2
MF:C8H15NO4
Melting point :76-78 °C
form:powder
color:White or off-white
Uses:
Boc-beta-alanine, formally named N-(tert-Butoxycarbonyl)-beta-alanine (also written as Boc-β-Ala-OH), is a protected β-amino acid derivative. It is produced by attaching a Boc (tert-butoxycarbonyl) protecting group to the amino group of β-alanine (3-aminopropanoic acid).
| Property | Detail |
|---|---|
| CAS Number | 3303-84-2 |
| Molecular Formula | C₈H₁₅NO₄ |
| Molecular Weight | 189.21 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 76–78 °C |
| Solubility | Slightly soluble in DMSO and methanol; soluble in ethyl acetate |
| Purity | ≥98% (HPLC) |
| Storage | 2–8 °C, sealed, dry, dark place |
The molecule has two key functional groups:
Boc protecting group — shields the amine from unwanted side reactions during synthesis; can be cleanly removed under mild acidic conditions (e.g., TFA).
Terminal carboxylic acid — serves as a reactive site for amide bond formation with primary amines using coupling agents like EDC or HATU.
Primary Uses
1. Peptide Synthesis (Core Application)
Boc-beta-alanine is a standard building block in both solution-phase and solid-phase peptide synthesis (SPPS), particularly in the Boc-SPPS strategy. It introduces β-alanine residues into peptide chains with high efficiency and minimal side reactions.
2. PROTAC Linker
The compound is used as a linker in the synthesis of PROTACs (Proteolysis Targeting Chimeras), a rapidly advancing area in drug discovery. Its terminal carboxylic acid can form stable amide bonds, while the Boc group can be selectively deprotected for controlled chain elongation.
3. Medicinal Chemistry & Drug Development
Used as a building block for synthesizing novel therapeutics and bioactive compounds, including quinazolines (platelet aggregation inhibitors and integrin ligands).
Helps improve pharmacokinetic and pharmacodynamic profiles of drug candidates.
4. Synthesis of L-Carnosine
Boc-beta-alanine serves as a precursor for the preparation of L-carnosine, a dipeptide with antioxidant and anti-aging properties.
5. Energy Supplements
As a β-alanine derivative, it falls within the category of amino acid derivatives used commercially as ergogenic (performance-enhancing) supplements. These influence anabolic hormone secretion, fuel supply during exercise, mental performance under stress, and prevention of exercise-induced muscle damage.
Key Selling Points
Non-chiral (achiral) structure — Unlike most amino acids, β-alanine has no chiral center, eliminating risks of racemization and simplifying synthesis and purification.
Mild, clean deprotection — The Boc group is removed under mild acidic conditions (TFA), producing only gaseous CO₂ and volatile isobutylene as byproducts — easy to remove, no residue.
Simple molecular structure — Its straightforward architecture minimizes synthetic complexity, reduces side reactions, and facilitates efficient coupling with other building blocks.
Dual reactivity — The combination of a protected amine (Boc) and a free carboxylic acid provides orthogonal reactivity, enabling precise sequential synthesis strategies.
High purity & stability — Available at ≥98% purity (HPLC), stable at room temperature when properly stored, making it practical for routine laboratory use.
Versatile platform — Applicable across peptide synthesis, PROTAC development, medicinal chemistry, and supplement formulation — a single compound serving multiple high-value markets.
Wide commercial availability — Offered by major suppliers (Sigma-Aldrich, TCI, Alfa Aesar, Merck/Novabiochem, etc.) in various scales from grams to bulk, with competitive pricing.
In summary, Boc-beta-alanine is a fundamental, versatile protected amino acid building block whose achiral nature, clean deprotection chemistry, and dual reactivity make it indispensable in peptide synthesis, drug discovery (especially PROTACs), and medicinal chemistry.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Boc-beta-alanine with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Boc-beta-alanine.
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