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Polyinosinic acid-polycytidylic acid (poly(I:C)) is a synthetic double-stranded RNA molecule composed of inosinic and cytidylic acids. It mimics viral RNA and strongly activates the innate immune system by binding to toll-like receptor 3 (TLR3) and other pattern recognition receptors. Widely used in research, poly(I:C) serves as a potent immune stimulant to study antiviral responses, inflammation, and vaccine adjuvants. It’s also explored in cancer immunotherapy to boost immune recognition of tumors. In veterinary medicine, it’s used as an antiviral agent or adjuvant in some vaccines. Due to its ability to induce interferons and cytokines, it helps model viral infections without live viruses. While not approved for routine human therapeutic use, it remains a critical tool in immunology and drug development for understanding immune activation and developing novel treatments against infections and cancer.
Items | Specifications | Results |
Appearance | White Powder | Conforms |
Identification | Maximum absorption occurs at a wavelength of 266±2nm; There is minimum absorption at the wavelength of 228±2nm | λmax=266nm λmin=229nm |
Add the solution ofethidium bromide in its aqueous solution, observing at 254nm wavelength, fluorescence enhanced obviously | Conforms | |
PH | 7.0~9.0 | 8.4 |
Loss on drying | ≤10% | 5.7% |
Transmittance of solution | ≥98.0% | 99.3% |
Hyperchromic Effect | ≥55.0% | 58.6% |
Settlement coefficient | ≥4s | >4s |
Contents | 45.0%~55.0% | 50.0% |
Bacterial Endotoxins | ≤5EU/mg | Conforms |
Conclusion | The product conforms to the above specifications. | |
Polyinosinic acid-polycytidylic acid, commonly abbreviated as Poly(I:C), is a synthetic double-stranded RNA (dsRNA) molecule composed of two complementary homopolymers:
Polyinosinic acid (poly(I)) – a polymer of inosine
Polycytidylic acid (poly(C)) – a polymer of cytidine
These strands form a stable double-helix structure through Watson–Crick base pairing (I:C pairs), mimicking viral dsRNA — a molecular pattern typically produced during viral replication.
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