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3α-Hydroxy-7-oxo-5β-cholanic acid is a bile acid metabolite formed during the oxidation of chenodeoxycholic acid, primarily in the liver and gut. It features a hydroxyl group at position 3α and a keto group at position 7 on a 5β-cholanic acid backbone. This compound serves as an intermediate in bile acid metabolism and may be further converted to lithocholic acid by gut bacteria. While not used therapeutically, it plays a key role in research on bile acid synthesis, transport, and signaling pathways involving receptors like FXR and TGR5. It also acts as a biomarker in studies of liver function, cholestasis, and gut microbiome activity. Elevated levels can indicate metabolic disturbances or dysbiosis. Though not a drug itself, understanding its behavior helps advance treatments for liver and metabolic diseases, including NAFLD and bile acid diarrhea.
3α-Hydroxy-7-oxo-5β-cholanic acid is a bile acid derivative, specifically an oxidized metabolite of chenodeoxycholic acid (CDCA), a primary bile acid synthesized in the liver from cholesterol.
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