Name: Chemical Factory Supplier Bulk Price Top Quality Carbamazepine CAS 298-46-4 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance(25℃)	White to Off-white Powder	White Powder
Identification	IR:Corresponding to the spectrum of reference standard	Corresponding to the spectrum of reference standard
Identification	UPLC:Retention time of the sample conforms to that of the reference standard	Retention time of the sample conforms to that of the reference standard
X-ray Diffraction	Corresponding to Reference Spectrum	Corresponding to Reference Spectrum
Acidity	≤1.0ml/g(0.010mol/L NaOH)	Conform With
Alkalinity	≤1.0ml/g(0.010mol/L HCL)	Conform With
Loss on Drying	≤0.5%	0.09%
Chlorides	≤ 0.014%	＜0.014%
Residue on ignition	≤ 0.1%	＜0.05%
10,11-Dihydrocarbamazepine	≤ 0.2%	＜0.05%
Iminostilbene	≤ 0.2%	＜0.05%
Any Other Impurity	≤ 0.2%	＜0.05%
Total Impurities	≤0.5%	＜0.05%
UPLC Assay(Dried Basis)	98.0~102.0%	100.3%
Residual Solvents	Methanol:≤3000ppm Ethanol:≤5000ppm Chlorobenzene:≤360ppm	＜300ppm ＜500ppm ＜36ppm
Conclusion	The product conforms to the above specifications.

Carbamazepine is a prescription medication primarily classified as an anticonvulsant (anti-seizure drug) and a mood stabilizer. Chemically, it is a tricyclic compound related to tricyclic antidepressants. It is widely known under brand names such as Tegretol, Carbatrol, and Epitol.

Its primary mechanism of action involves blocking voltage-gated sodium channels in neurons. By stabilizing the inactive state of these channels, it prevents the repetitive firing of nerve impulses that lead to seizures or nerve pain.

Here are its key selling points (clinical benefits and indications):

1. Gold Standard for Specific Seizure Types

Focal Seizures: It is considered a first-line treatment for focal (partial) seizures and generalized tonic-clonic seizures. It effectively reduces the frequency and severity of these episodes.

Long-Term Control: It has a proven track record for long-term management of epilepsy, allowing many patients to achieve seizure freedom.

2. First-Line Treatment for Trigeminal Neuralgia

Nerve Pain Relief: Carbamazepine is the drug of choice for trigeminal neuralgia, a debilitating condition causing intense facial pain. It is highly effective at dampening the abnormal electrical activity in the trigeminal nerve, providing significant pain relief where standard painkillers (like ibuprofen or opioids) often fail.

Other Neuropathic Pain: It is also used off-label for other types of neuropathic pain (e.g., diabetic neuropathy, glossopharyngeal neuralgia).

3. Mood Stabilization in Bipolar Disorder

Acute Mania: It is FDA-approved for the treatment of acute manic or mixed episodes in bipolar I disorder.

Alternative to Lithium: It serves as a crucial alternative for patients who do not respond to or cannot tolerate lithium. It helps stabilize mood swings and prevent recurrence of manic episodes.

4. Versatile Formulations

Extended-Release Options: Available in extended-release (ER) formulations (e.g., Carbatrol, Tegretol-XR), which allow for twice-daily dosing. This improves patient compliance by maintaining stable blood levels and reducing peak-related side effects like dizziness or drowsiness.

Important Considerations (Not "Selling Points" but Critical Context)

While effective, Carbamazepine has significant safety considerations that distinguish it from newer drugs:

Drug Interactions: It is a potent inducer of liver enzymes (CYP450 system), meaning it speeds up the metabolism of many other drugs (including birth control pills, blood thinners, and other anti-seizure meds), potentially making them less effective.

Genetic Screening: Patients of Asian descent are often screened for the HLA-B*1502 allele before starting therapy, as its presence significantly increases the risk of severe, life-threatening skin reactions (Stevens-Johnson Syndrome).

Monitoring Required: Regular blood tests are needed to monitor drug levels, liver function, and blood cell counts due to risks of toxicity and rare blood disorders (aplastic anemia).

In summary, Carbamazepine’s main "selling points" are its proven efficacy as a first-line therapy for focal epilepsy and trigeminal neuralgia, its role as a robust mood stabilizer, and the availability of extended-release formulations for convenient dosing, despite its complex interaction profile.