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Promethazine hydrochloride has a cough suppressant effect, can competitively block the histamine H1 receptor and produce antihistamine effect, antihistamine caused by capillary dilation, and reduce its permeability.
Promethazine hydrochloride is a phenothiazide antihistamine that can also be used for antiemetic, anti-motion sickness, and sedative hypnosis. 1. Antihistamine effect: it competes with the histamine released by the tissue for H1 receptors, can antagonize the contraction or contracture of histamine on the smooth muscle of the gastrointestinal tract, trachea, bronchi or bronchioles, and relieve the spasmogenic and congestive effect of histamine on bronchial smooth muscle. 2. Antiemetic effect: It may be related to the chemoreceptor area that inhibits the emetic inhibition of the medulla oblongata. 3. Anti-motion sickness: It may act on vestibular and vomiting centers and medullary receptors in the vestibular and vomiting centers through central anticholinergic properties, mainly blocking the excitement of cholinergic synaptic labyrinthine impulses in the vestibular nucleus area. 4. Sedative hypnotic effect: may be due to indirect reduction of the stress of the reticular ascending activation system of the brainstem.
| Items | Specifications | Results |
| Appearance | White or faintly yellowish crystalline powder | Conforms |
| Acidity | 4.0~5.0 | 4.2 |
| Loss on drying | ≤0.50% | 0.10% |
| Sulphated ash | ≤0.10% | 0.05% |
| Assay | 99.0~101.0% | 100.5% |
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| Product parameters | |
| Cas number: | 58-33-3 |
| Appearance: | White or faintly yellowish crystalline powder |
| Purity: | 99~101% |
| Package details: | 1kg/foil bag; 25kg/drum |
| Brand: | Fortunachem |
For the treatment of allergic disorders, and nausea/vomiting.
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