Cabazitaxel is used to treat prostate cancer. Cabazitaxel is a semisynthetic taxane derivative that acts as a microtubule inhibitor. It binds to tubulin, promoting the assembly of tubulin into microtubules and inhibiting their disassembly, which results in microtubule stabilization, the inhibition of cell division, cell cycle arrest and the arrest of tumour proliferation. Cabazitaxel demonstrated antitumour activity against advanced human tumours xenografted in mice. As well as being active in docetaxel-sensitive tumours, cabazitaxel showed activity in tumour models insensitive to chemotherapy, including docetaxel. Cabazitaxel also penetrates the blood-brain barrier to a greater extent than docetaxel.
|Appearance||White or off-white powder||Conforms|
|Appearance:||White or off-white powder|
|Package details:||10g/bottle; 100g/foil bag|
A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer.
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