Name: Chemical Factory Top Quality Best Price 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic Acid CAS 7365-44-8 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Detailed Description

Specifications of 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic Acid CAS 7365-44-8 COA:

Items	Specifications	Results
Appearance	White crystal powder	Qualified
Content,%	99.0%-101.0%	99.5%
Solubility(1M aq.)	Clear,colorless solution	Qualified
Water Content,%(K.F)	≤1.0	0.59
Ultraviolet absorbance/260nm(0.1M aq.)	≤0.06	0.042
Ultraviolet absorbance/280nm(0.1M aq.)	≤0.05	0.031
Conclusion	The product conforms to the above specifications.

Parameters of 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic Acid CAS 7365-44-8

Product parameters
Cas number:	7365-44-8
Appearance:	White crystalline powder
Purity:	99%-101%
MOQ:	1kg
Price:	Negotiable
Package details:	1kg/foil bag;25kg/drum
Brand:	Fortunachem

Uses:

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid (TES)

TES is a zwitterionic biological buffer belonging to the "Good's buffers" family, first characterized by Norman Good and colleagues in 1966. Its molecular formula is C₆H₁₅NO₆S (MW: 229.25 g/mol, CAS: 7365-44-8). Structurally, TES is a Tris analog — it retains the tris(hydroxymethyl)methyl amino group but adds an ethanesulfonic acid group (–CH₂CH₂SO₃H), giving it zwitterionic character at physiological pH.

TES appears as a white crystalline powder, highly soluble in water (up to 500 mg/mL), with a pKa of 7.55 at 25°C and a useful buffering range of pH 6.8–8.2 — squarely at physiological pH.

Key Selling Points

Physiological pKa (7.55) — ideal for experiments replicating blood and cellular conditions

Low temperature sensitivity — ΔpKa/°C = –0.020, significantly better than Tris (–0.031), ensuring stable pH across temperature shifts (4°C to 37°C)

Minimal metal ion binding — preserves essential enzyme cofactors (Mg²⁺, Ca²⁺, Zn²⁺), unlike Tris which can sequester them

UV transparency — absorbance ≤ 0.05 at 250 nm, ideal for spectrophotometric assays and nucleic acid quantification

Zwitterionic — no net charge at working pH, minimal ionic strength effects

Chemically inert — does not form Schiff bases (unlike Tris), enzymatically stable, no side reactions with biomolecules

BCA assay compatible — suitable for bicinchoninic acid protein quantification

High water solubility — easy buffer preparation via NaOH titration

Main Uses

Protein purification & crystallization — maintains native conformation; low metal binding preserves metalloprotein cofactors

Enzyme kinetics — stable pH ensures accurate reaction rate measurements; restriction enzymes show 18–22% higher efficiency in TES vs. HEPES

Nucleic acid research — DNA/RNA extraction, restriction digestion, and gel electrophoresis with superior pH stability

Cell culture & virology — supports mammalian cell growth (HeLa, BHK 21) and viral plaque assays at 25–50 mM; used in semen preservation media (Test Yolk Buffer)

Pharmaceutical development — buffer excipient for biologic drug purification and formulation

Analytical chemistry — background electrolyte in capillary electrophoresis; compatible with UV-Vis spectroscopy

Cosmetics — pH buffering agent in skincare formulations

TES vs. Tris vs. HEPES

Property	TES	Tris	HEPES
pKa (25°C)	7.55	8.08	7.55
ΔpKa/°C	–0.020	–0.031	–0.014
Metal binding	Low	Moderate	Low
Schiff base formation	No	Yes	No

In short, TES's core advantage is its physiological pKa combined with low temperature dependence and minimal metal binding — making it the preferred buffer when precise pH control near 7.4 is required across varying temperatures, particularly in enzyme work, protein studies, and cell culture where Tris's limitations would compromise results.

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic Acid with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic Acid.

Our Advantages:

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

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