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Sulfachloropyrazine sodium is a special sulfonamide drug against coccidiosis and is widely used in livestock and poultry coccidiosis.
Sulfachloropyrazine sodium can compete for dihydrofolate synthase to affect the synthesis of dihydrofolate, thereby inhibiting the growth and reproduction of bacteria and coccidioides. The effect of sulfaclopyrazine sodium on poultry coccidiosis is similar to that of sulfaquinoxaline, but has a stronger antibacterial effect, and can even treat avian cholera and chicken typhoid, so it is most suitable for treatment in coccidiosis outbreaks.
Items | Specifications | Results |
Appearance | White or yellowish powder | yellowish powder |
Identification（1） | The principal spot in TLC chromatogram obtained in position and size corresponds with Sulfachlorpyrazine Sodium CRS. | Complies |
Particle | 500um~40um Not more than 1%，Not less than 17% | Complies |
Identification（2） | Identical with the spectrum obtained with CRS | The IR spectrum of the sample corresponds to the IR spectrum of the RS |
Identification（3） | Is the first identification of aromatic amines | Positive reaction |
Alkalinity | pH 9.0-10.5 | 10.1 |
Clarity of the solution | Clarify | Clarify |
Related substances | The color of a single impurity should not be greater than that of the control solution （3.0%） | Conforms |
Water | Not more than 6.5% | 5.4% |
Heavy metals | Not more than 20ppm | Less than 20ppm |
Arsenide | Not more than 2ppm | Less than 2ppm |
Assay | NLT 99.0% of C10H8ClN4NaO2S·H2O, Caculate on anhydrous | 99.6% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 102-65-8 |
| Appearance: | White to yellowish crystalline powder |
| Purity: | 99%min |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Uses:
Sulfachloropyrazine Sodium (CAS 102-65-8)
Sulfachloropyrazine Sodium , commonly known as "Esb3" or "Three-Character Coccidiosis Powder" , is a sulfonamide-class veterinary pharmaceutical compound primarily used as an anti-coccidial and antibacterial agent. Its chemical name is N-(5-chloro-pyrazine)-4-aminobenzenesulfonamide sodium salt monohydrate, with the molecular formula C₁₀H₈ClN₄NaO₃S·H₂O and a molecular weight of approximately 324.72.
Physical Properties:
Appearance: White to pale yellow powder, odorless
Solubility: The sodium salt form is highly water-soluble (a key advantage over the free acid form)
Stable at pH 3–7
Melting point: ~234.8–235.4°C
Mechanism of Action: It competes with para-aminobenzoic acid (PABA) for the enzyme dihydrofolate synthetase, blocking the synthesis of dihydrofolic acid → tetrahydrofolic acid → nucleic acids, thereby inhibiting the growth and reproduction of coccidia and bacteria.
Primary Uses
1. Anti-Coccidial Application (Core Use)
Target species: Chickens, turkeys, rabbits, sheep, goats, ducks, and geese
Peak activity period: Second-generation schizonts of coccidia (Day 4 post-infection); also effective against first-generation schizonts
Ideal scenario: Emergency treatment during coccidiosis outbreaks — not intended for long-term prophylactic use
Controls clinical signs including bloody diarrhea, weight loss, intestinal hemorrhage, and mass mortality
2. Antibacterial Application (Dual Function)
Strong activity against Pasteurella (fowl cholera) and Salmonella (fowl typhoid)
Particularly valuable when coccidiosis outbreaks are complicated by secondary bacterial infections (necrotic enteritis, septicemia)
3. Species-Specific Applications
| Animal | Indication | Route | Duration |
|---|---|---|---|
| Broilers/Turkeys | Coccidiosis, fowl cholera | Drinking water / feed | 3 days (max 5) |
| Rabbits | Intestinal & hepatic coccidiosis | Feed / water / oral | 5–10 days |
| Lambs/Goats | Coccidiosis (15–60 day old) | Oral (10% solution) | 3–5 days |
| Dogs/Cats | Toxoplasmosis (off-label) | Oral (vet-directed) | Per vet guidance |
Key Selling Points
✅ Dual Anti-Coccidial + Antibacterial Action
Unlike many single-target coccidiostats, Sulfachloropyrazine Sodium simultaneously treats coccidiosis and secondary bacterial infections (Pasteurella, Salmonella), reducing the need for multi-drug protocols during outbreaks.
✅ Does NOT Suppress Host Immunity
A critical advantage: it does not interfere with the host's ability to develop natural immunity against coccidia. Animals recover and build protective immunity post-treatment, which is essential for long-term flock health management.
✅ Rapid Absorption & High Bioavailability
After oral administration, it is rapidly absorbed in the GI tract with peak blood concentration reached within 3–4 hours, and is quickly excreted via kidneys — ensuring effective tissue drug levels with minimal residual accumulation.
✅ Excellent Water Solubility (Sodium Salt Form)
The sodium salt formulation dissolves readily in water, making it ideal for mass medication via drinking water systems — crucial during outbreak scenarios when rapid, flock-wide treatment is needed.
✅ Short Withdrawal Period
Broilers: 1 day
Turkeys: 4 days
This makes it practical for use in meat production operations where turnaround time matters.
✅ Flexible Combination Therapy
Compatible with multiple synergistic partners:
TMP/DVD (antibacterial potentiators) → 10x enhanced antibacterial effect
Amprolium → broadened anti-coccidial spectrum (cecal + intestinal)
Ethopabate → enhanced anti-coccidial efficacy
Vitamin K3 → rapid hemorrhage control
✅ Proven Global Market Position
China is the world's primary production and export base for this API. The global soluble powder market was valued at approximately ¥5 billion (RMB) in 2024, projected to reach ¥6 billion by 2031, driven by rigid demand from the poultry sector.
Important Limitations to Note
Not for long-term use — maximum 3–5 consecutive days to avoid toxicity and resistance
Contraindicated in laying hens and birds over 16 weeks of age
Incompatible with acidic drugs, salinomycin, and nicarbazin
Resistance development is a concern with prolonged/repeated use; rotation with other coccidiostats (e.g., diclazuril, decoquinate) is recommended
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Sulfachloropyrazine Sodium with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Sulfachloropyrazine Sodium.
1. Guaranteed purity;
2. Large quantity in stock;
3. Largest manufacturer;
4. Best service after shipment with email;
5. High quality & competitive price;
Fortunachem Provides Not Only Professional Chemical Products But Also Professional Help
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