Name: China Factory Supply Top Purity Good Service Sodium Taurocholate CAS 145-42-6
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Sodium Taurocholate CAS 145-42-6

Items	Specifications	Results
Appearance	White or almost white powder	Conforms
Purity	≥95%	96.6%

Parameters of Sodium Taurocholate CAS 145-42-6

Product parameters
Cas number:	145-42-6
Appearance:	White or almost white powder
Purity:	95% min
MOQ:	1kg
Price:	Negotiable
Package details:	1kg/foil bag
Brand:	Fortunachem

Sodium taurocholate is the sodium salt of taurocholic acid, a primary bile acid that plays a critical role in the human digestive system. It is classified as a conjugated bile salt, meaning it is synthesized in the liver by combining cholic acid (a classic steroid-based bile acid) with the amino acid taurine. This conjugation process significantly enhances its solubility and effectiveness in the intestine.

Chemical Structure and Properties

Its chemical structure is key to its function. Like other bile salts, it has a characteristic steroid (cyclopentanoperhydrophenanthrene) nucleus. This core is amphiphilic, meaning it has both hydrophobic (water-repelling) and hydrophilic (water-attracting) regions:

Hydrophobic Side: The steroid ring system is fat-soluble and interacts with dietary lipids.
Hydrophilic Side: The side chain ends with a sulfonate group (-SO₃⁻) from the taurine moiety, which is highly water-soluble.

This unique structure makes sodium taurocholate a potent biological detergent. It is a major component of bile, which is stored in the gallbladder and released into the duodenum (the first part of the small intestine) after a meal.

Primary Biological Function: Fat Digestion and Absorption

Its most crucial role is in the emulsification and absorption of dietary fats and fat-soluble vitamins (A, D, E, and K).

Emulsification: When released into the intestine, sodium taurocholate surrounds droplets of dietary triglycerides (fats), breaking them down into a fine emulsion of microscopic droplets. This process drastically increases the surface area of the fat, making it accessible for the digestive enzyme pancreatic lipase.
Micelle Formation: After lipase breaks down triglycerides into fatty acids and monoglycerides, sodium taurocholate aggregates with these products to form structures called mixed micelles. These micelles are tiny spheres with a hydrophobic core and a hydrophilic exterior, allowing them to shuttle insoluble lipids through the watery environment of the intestinal lumen to the brush border membrane of the intestinal cells (enterocytes) for absorption.

Significance in Research and Medicine

Beyond its natural function, sodium taurocholate is widely used in scientific and medical contexts:

Drug Delivery: It is studied as a permeability enhancer to improve the absorption of poorly absorbed drugs, especially in oral formulations.
Biochemistry Reagent: It is a common reagent used to simulate intestinal conditions in in vitro experiments to study drug solubility and permeability (e.g., in the simulated intestinal fluid for dissolution testing).
Cell Biology: It is used to solubilize membrane proteins and lipids in laboratory procedures.

In summary, sodium taurocholate is an essential conjugated bile salt whose detergent-like properties are indispensable for the efficient digestion and absorption of dietary fats, while also serving as a valuable tool in pharmaceutical and biochemical research.