Simvastatin has the effect of lowering cholesterol, low density lipoprotein. Simvastatin catalyzes the conversion of β-methyl-β-hydroxyglutaric acid coenzyme A (HMG-CoA) to β methyl-p-α dihydroxyvalerate, and is a specific inhibitor of HMG-CoA reductase. Simvastatin is used in primary hypercholesterolemia, heterozygous familial and nonfamilial hypercholesterolemia, or mixed hyperlipidemia that do not respond well to dietary therapy, and has a significant effect on reducing total cholesterol and LDL cholesterol.
|Appearance||White or almost white crystalline powder||Almost white crystalline powder|
|Specific optical rotation||+285°~+300°||+291.2°|
|Related substance||Impurity A≤0.4%|
Any unspecified impurity≤0.1%
|Loss on drying||≤0.5%||0.03%|
|Appearance:||White or almost white crystalline powder|
|Package details:||1kg/foil bag;25kg/drum|
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