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Pyrazinamide has a good antibacterial effect on Mycobacterium tuberculosis human, and when the pH value is between 5-5.5, the bactericidal effect is the strongest, especially for tuberculosis bacteria in phagocyte that grow slowly in an acidic environment. After pyrazinamide penetrates into phagocytes and enters Mycobacterium tuberculosis, the amide enzyme in the bacteria deactivates the amide group and converts it into pyrazine acid to play an antibacterial effect. Pyrazinamide has an inhibitory effect on intracellular Mycobacterium tuberculosis, which can enter the cell and enter the brain tissue through the blood-brain barrier to kill Mycobacterium tuberculosis; It has a unique sterilization effect on semi-dormant bacteria that are slowly metabolized in macrophages, so it is one of the main drugs for short-course chemotherapy for tuberculosis.
Pyrazinamide is an important anti-tuberculosis drug, which is mainly used for chronic tuberculosis, fever, cough, sputum and so on.
| Item | Specifications | Results |
| Appearance | White or almost white crystalline powder | White crystalline powder |
| Heavy Metal | ≤10ppm | Conform |
| Sulphate ash | ≤0.1% | 0.04% |
| Water | ≤0.5% | Conform |
| Assay | 99.0% - 101.0% | 99.7% |
| Product parameters | |
| Cas number: | 98-96-4 |
| Appearance: | White or almost white crystalline powder |
| Purity: | 99.0% - 101.0% |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Pyrazinamide is taken up by Mycobacterium tuberculosis (the bacteria that causes TB) and converted to its active form, pyrazinoic acid, by the bacterial enzyme pyrazinamidase.
Pyrazinoic acid disrupts the acid-base balance inside the bacterial cell, inhibits fatty acid synthesis, and damages the bacterial cell membrane, ultimately leading to bacterial death.
It is most effective against M. tuberculosis that resides in the acidic environment of macrophages (immune cells that engulf bacteria), a niche where other first-line TB drugs (e.g., isoniazid, rifampicin) are less potent.
This combination therapy reduces the risk of drug resistance and ensures complete elimination of the bacteria.
It is effective for both pulmonary TB (affecting the lungs) and extrapulmonary TB (affecting organs like the lymph nodes, bones, or kidneys).
Drug Resistance: Monotherapy with pyrazinamide is strictly prohibited, as it rapidly leads to the development of resistant M. tuberculosis strains.
Side Effects: The most common side effect is hyperuricemia (elevated uric acid levels in the blood), which can trigger gout. Other side effects include hepatotoxicity (liver damage), gastrointestinal disturbances, and skin rashes.
Contraindications: It is contraindicated in patients with severe liver disease or a history of gout, and requires dose adjustment in patients with renal impairment.
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