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Pyrazinamide has a good antibacterial effect on Mycobacterium tuberculosis human, and when the pH value is between 5-5.5, the bactericidal effect is the strongest, especially for tuberculosis bacteria in phagocyte that grow slowly in an acidic environment. After pyrazinamide penetrates into phagocytes and enters Mycobacterium tuberculosis, the amide enzyme in the bacteria deactivates the amide group and converts it into pyrazine acid to play an antibacterial effect. Pyrazinamide has an inhibitory effect on intracellular Mycobacterium tuberculosis, which can enter the cell and enter the brain tissue through the blood-brain barrier to kill Mycobacterium tuberculosis; It has a unique sterilization effect on semi-dormant bacteria that are slowly metabolized in macrophages, so it is one of the main drugs for short-course chemotherapy for tuberculosis.
Pyrazinamide is an important anti-tuberculosis drug, which is mainly used for chronic tuberculosis, fever, cough, sputum and so on.
|Appearance||White or almost white crystalline powder||White crystalline powder|
|Assay||99.0% - 101.0%||99.7%|
|Appearance:||White or almost white crystalline powder|
|Purity:||99.0% - 101.0%|
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