Pinaverium bromide is used to treat gastrointestinal spastic pain, hyperperistalsis, irritable bowel syndrome, and gallbladder dyskinesia.
Pinaverium bromide exerts an antispasmodic effect by inhibiting the flow of calcium ions into smooth muscle cells of the intestinal wall and preventing excessive muscle contraction. PPinaverium bromide has a low affinity for cardiovascular smooth muscle cells and does not cause changes in blood pressure. It eliminates the hyperreactivity of intestinal smooth muscle and increases intestinal peristalsis. Pinaverium bromide is mainly used for the symptomatic treatment of abdominal pain, defecation disorders, and intestinal discomfort associated with irritable bowel syndrome, for pain and gallbladder dyskinesia associated with biliary dysfunction, and in preparation for barium enemas.
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