Olaparib is used to treat recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Olaparib is a novel poly ADP ribose polymerase (PARP) inhibitor that includes PARP1, PARP2, and PARP3. PARP mediates a DNA repair mechanism that plays an important role in DNA damage repair and apoptosis, so olaparinite acts on the DNA damage repair mechanism of targeted cells, works by attacking key loopholes in cancer cells carrying BRCA1 and BRCA2 mutations, and can be used for maintenance therapy in patients with recurrent severe ovarian cancer with breast cancer susceptibility gene (BRCA) mutations and sensitive to platinum drugs.
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