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Medroxyprogesterone acetate (MPA, API)
Medroxyprogesterone acetate (CAS 71-58-9, C₂₄H₃₄O₄, MW 386.52) is an off-patent synthetic steroidal progestin—a stable, crystalline, water-insoluble powder made by chemical synthesis.
Uses: long-acting injectable contraception (DMPA-IM/SC, WHO Essential Medicines List), HRT endometrial protection, amenorrhea and abnormal uterine bleeding, endometriosis, palliative treatment of breast and endometrial cancer, veterinary estrus control, plus research and analytical reference standards.
API selling points: dual demand from contraception tenders and women's-health generics; mature, scalable chemistry; ambient shipping with no cold chain; micronized grades with controlled PSD/polymorph for depot suspensions—ensuring syringeability, dose uniformity, and consistent 3-month release; tight related-substance profiles; full DMF/GMP/CTD dossiers with real-time stability; co-supply of impurity standards and deuterated IS; plus reliable lead times.
Caveats: prescription hormone only (thromboembolism, boxed warning for bone-mineral-density loss); never a supplement or bodybuilding ingredient; requires GMP status, contained steroid handling, cross-contamination controls, and proper disposal.
Specifications of N-Acetyl-L-cysteine CAS 616-91-1 COA:
Items | Specifications | Results |
Appearance | White to off-white,odorless,powder. | Conform |
Solubility | Freely soluble in chloroform;soluble in acetone and in dioxane;sparingly soluble in alcohol and in methanol;slightly soluble in ether;in soluble in water. | Conform |
Specific optical rotation | +45~+51° | +50.0 |
Melting point | About 205℃ | 205.1-206.6℃ |
Chromatographic purity Any individual impurity Total impurities | ≤1.0% ≤1.5% | 0.26% 0.78% |
Loss on drying | ≤1.0% | 0.17% |
Related compound A | ≤0.50% | 0.06% |
Assay (HPLC) | 97.0~103.0% | 99.16% |
Related solvents | Methanol ≤3000 ppm Methylene chloride ≤600ppm | Not detected 102ppm |
Micron | 100%≤20μm | 100%≤20μm |
Conclusion | The product conforms to the above specifications. | |
Product Name:Medroxyprogesterone Acetate
CAS:71-58-9
MF:C24H34O4
Melting point :205.1-206.6℃
form:powder
color:White to off-white
Uses:
Medroxyprogesterone acetate (MPA) is a synthetic steroidal progestin — the 17α-acetate of 17α-hydroxy-6α-methylprogesterone. It is a small, lipophilic, orally active steroid made by chemical synthesis (typically microbiological or chemical 6α-methylation of 17α-hydroxyprogesterone followed by acetylation). Off-patent for decades, it is one of the world's highest-volume progestin APIs because it anchors both hormone-replacement therapy and long-acting injectable contraception.
| Item | Detail |
|---|---|
| CAS No. | 71-58-9 |
| Synonyms | 6α-methyl-17α-acetoxyprogesterone; Provera / Depo-Provera API; MAP |
| Molecular formula / weight | C₂₄H₃₄O₄ · 386.52 Da |
| EINECS / MDL | 200-758-0 · MFCD00003719 |
| Appearance | White to off-white crystalline powder |
| Melting point | ~200–210 °C (decomp.); literature 204–207 °C |
| Optical rotation | [α]D²⁰ ≈ +59° to +63° (c 1, dioxane) |
| Solubility | Practically insoluble in water; soluble in acetone/chloroform/dioxane, sparingly soluble in ethanol |
| Stability / storage | Chemically robust crystalline solid; well-closed container, protected from light; ambient/cool & dry — no cold chain |
| PK notes | Oral t½ a few hours; IM depot (DMPA) effective t½ ≈ 5–6 weeks, detectable 6–12 months after last injection |
| HS code | 2937.23 (steroid hormones) |
| Typical assay/spec | 97.0–103.0% (anhydrous basis); water ≤0.5%, ROI ≤0.2%, heavy metals ≤20 ppm |
Main uses
1. Human clinical (prescription)
Contraception — long-acting reversible (the volume driver): DMPA-IM 150 mg/1 mL every 3 months; DMPA-SC 104 mg/0.65 mL (Sayana Press/Depo-subQ) enabling self-injection; included on the WHO Model List of Essential Medicines and procured at scale by UN/global family-planning programs.
Gynecology: secondary amenorrhea, abnormal uterine bleeding/dysfunctional uterine bleeding, endometriosis, endometrial protection in menopausal HRT (combined with estrogens), luteal support.
Oncology (palliative): advanced hormone-dependent breast cancer and endometrial carcinoma (high dose).
Prostate cancer: high-dose palliative/antiandrogen use in some markets.
Dosage forms: tablets, injectable aqueous suspensions (micronized), combined injectables (with estradiol enanthate/cypionate), vaginal and transdermal combinations in some regions.
2. Veterinary
Estrus suppression/synchronization in dogs and mares, management of behavioral/reproductive disorders, pregnancy termination in some protocols. Same API, separate registration track.
3. Research & analytical
Progesterone receptor agonist with AR antagonism and glucocorticoid activity — used in endometrial biology, endometriosis and fibroid models, breast/prostate cancer cell studies, bone-density and hypothalamic-pituitary axis research, cachexia/neurosteroid work.
Analytical reference standard for finished-product QC; pharmacopeias list multiple related substances (free medroxyprogesterone alcohol, 6β-epimer, Δ1-dehydro, hydroxy/deacetyl degradants), so labs need the main standard plus impurity standards.
Selling points — API grade
A. Commercial
Two permanent demand engines: HRT/gynecology generics plus long-acting injectable contraception, which is bought in multi-year public-health tenders (UNFPA/WHO-prequalified programs) → predictable, policy-backed volumes.
Off-patent, guideline-anchored, recession-resistant — contraception and menopause care are non-discretionary; demand grows with population and access programs.
Dual human + veterinary channel from one molecule; additional revenue from reference standards and deuterated/internal standards for LC-MS.
Mature, scalable chemistry from sterol feedstock; cost driven by process efficiency, documentation and consistency rather than raw-material scarcity.
Excellent logistics economics: stable crystalline solid, ambient/light-protected shipment, no cold chain, low freight and spoilage risk.
B. Technical (what formulators actually pay a premium for)
6. Particle-size & crystal-form control for injectable suspensions — this is the #1 differentiator vs. other progestins. Micronized material with defined PSD (D10/D50/D90), narrow distribution, controlled polymorph/habit and low fines ensures syringeability, dose uniformity, resistance to Ostwald ripening/crystal growth in vials, and consistent release over 12–13 weeks. Qualified-for-depot grades command premium pricing.
7. Oral-solid performance: flowable, compressible grades with consistent PSD for tablets and fixed-dose HRT combinations.
8. Tight related-substance profile: quantified free alcohol, 6β-epimer, Δ1 analog, residual starting materials/solvents; individual unknown ≤0.10%; validated stability-indicating HPLC; ICH Q3C/Q3D/Q3M compliance plus nitrosamine risk assessment.
9. Full regulatory package: GMP site, DMF/ASMF (US/EU), CEP where available, CTD Module 3 support, letter of access, real-time stability (24–36 months, Zones II/IVb), USP/EP/BP/ChP compliance.
10. Supply security: validated change control, retained samples, multi-line capacity, guaranteed lead times — generic customers prioritize stock-out avoidance over marginal price.
11. One-stop portfolio: co-supply of pharmacopeial impurities A/B/C…, working standards, and MPA-d3/deuterated IS for bioanalysis.
12. Flexible grading/packing: GMP pharma, pharma-intermediate, and research (≥98–99% HPLC) grades in 1 g–25 kg packs with fast dispatch, custom micronization and private-label COA support.
Important caveats
Prescription hormone API only. Contraindications include active or history of thromboembolism/thrombophlebitis, severe hepatic disease, undiagnosed vaginal bleeding, known/suspected breast cancer (except palliative oncology indication), and pregnancy. Warnings: boxed warning for bone-mineral-density loss with long-term DMPA use, mood changes/depression, weight gain, headache, irregular bleeding, hyperglycemia, rare anaphylaxis. All promotion must avoid unapproved claims.
Not a consumer/wellness or bodybuilding product. Do not position it as a supplement, "cycle support," or weight-control ingredient; research grade must carry "not for human/veterinary consumption."
Potent steroid handling. Requires appropriate OEL/OEB classification, contained processing, dedicated or campaign-based facilities with validated cleaning and cross-contamination controls (especially in shared steroid lines), environmental release prevention, and proper waste disposal.
Regulatory gatekeeping: human use requires national MA plus GMP API with filed DMF; contraceptive injectables face additional prequalification/tender requirements (e.g., WHO PQ); veterinary use needs separate registrations; export/import may require permits.
Verify suppliers: quoted prices vary widely and many listings are traders. Real differentiators are batch-specific COA + HPLC chromatogram, audit rights, and a traceable manufacturing site.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Medroxyprogesterone Acetate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Medroxyprogesterone Acetate.
1. Guaranteed purity;
2. Large quantity in stock;
3. Largest manufacturer;
4. Best service after shipment with email;
5. High quality & competitive price;
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