Name: Low-Substituted Hydroxyproxyl Cellulose (LH-21)
Brand: Wuhan Fortuna Chemical Co., Ltd.

Detailed Description

Specifications of Low-Substituted Hydroxypropyl Cellulose (LH-21) COA:

Items	Specifications	Results
Appearance	White or almost white powder, insoluble in ethanol or acetone.	Conform
Identification	Positive	Conform
Acidity or alkalinity	5.0~7.5	5.3
Chloride %	≤0.20	＜0.20
Loss on drying %	≤5.0	2.0
Residue on ignition %	≤1.0	0.21
Heavy metals %	≤0.001	＜0.001
Arsenic %	≤0.0002	＜0.0002
Assay(on the dried basis)%	5.0~16.0	11.1
Total Aerobic Microbial Count cfu/g	≤10³	120
Total Molds and Yeasts Count	≤10²	20
Escherichin Coll	Negative	Negative
Conclusion	The product conforms to the above specifications.

Parameters of Low-Substituted Hydroxypropyl Cellulose (LH-21)

Product parameters
Cas number:	N/A
Appearance:	White to yellow-white granular powder
Purity:	10.0-12.9%
Package details:	20kg/bag
Brand:	Fortunachem

Uses:

Low-Substituted Hydroxypropyl Cellulose (LH-21): Overview

LH-21 is the most widely used general-purpose grade of Low-Substituted Hydroxypropyl Cellulose (L-HPC, CAS: 9004-64-2), a non-ionic modified cellulose polymer produced by etherifying natural cellulose to introduce hydroxypropyl groups onto the molecular backbone.

With a hydroxypropoxy content of 10.0–12.9%, an average particle size of ~45 μm and moderately fibrous morphology, LH-21 is insoluble in water and common organic solvents but swells rapidly when exposed to moisture — this unique property delivers its dual functionality as both a binder and disintegrant.

Core Applications in Chemical & Pharmaceutical Fields

LH-21 is predominantly used as a high-performance excipient in oral solid dosage forms, and also serves as a functional additive in fine chemical, food and cosmetic formulations:

Wet granulation: dual-role binder + disintegrant

It is the industry standard grade for wet granulation processes: dosed at 2–4% internally as a binder to improve tablet hardness, friability and compactibility, and 1–2% externally to boost rapid disintegration in gastrointestinal fluids.

Direct compression tablets

Works effectively in direct compression formulations with balanced binding power and moderate anti-capping performance.

Bioavailability enhancement

Its rapid swelling action breaks tablets into fine particles, accelerating dissolution of poorly soluble active pharmaceutical ingredients (APIs) and improving in vivo bioavailability.

Other industrial uses

Functions as a stabilizer, emulsifier, suspending agent and thickener in food additives and cosmetic chemical systems.

Key Selling Points

Dual functionality in one material

Replaces separate binders and disintegrants, simplifying formulation design, reducing inventory SKUs and lowering overall production costs.

Universal process & formulation compatibility

The most versatile L-HPC grade, compatible with nearly all conventional tablet and capsule formulations, and adaptable to both wet granulation and direct compression manufacturing processes.

Excellent chemical inertness

Its non-ionic structure ensures broad compatibility with acidic, alkaline and neutral APIs/excipients; it does not trigger hydrolysis, discoloration or degradation of active ingredients, outperforming traditional starch and sodium carboxymethyl cellulose.

Stable long-term performance

Disintegration efficiency remains almost unaffected by storage time; it does not gelatinize or cause surface mottling after tablet compression.

Global regulatory compliance

Complies with USP, BP, EP and CP pharmacopoeia standards, making it fully suitable for international trade and global pharmaceutical markets.

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Low-Substituted Hydroxyproxyl Cellulose (LH-21) with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Low-Substituted Hydroxyproxyl Cellulose (LH-21).

Our Advantages:

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

5. High quality & competitive price;