Levosimendan is used in the treatment of acute heart failure.
Levosimendan has both calcium ion sensitizing activity and potassium channel opening effect, so it has both myocardial contractility enhancement and anti-ischemia and vasodilation effect, levosimendan can increase cardiac output, make blood vessels dilate, and reduce cardiac before and after load when improving cardiac pump function. Levosimendan does not directly increase the concentration of calcium ions in cardiomyocytes or increase troponin and affinity with Ca2+, but binds to the amino amino terminus of supramyotroponin C (Tnc) of myocardial fine muscle to increase the conformational stability of Tnc with Ca2+ complexes.
|Appearance||Yellow powder or crystalline powder||Conforms|
|Loss on drying||≤1.0%||0.71%|
|Appearance:||Yellow powder or crystalline powder|
|Package details:||10g/bottle; 100g/foil bag|
It is a troponin calcium agonist and is indicated for the treatment of acute heart failure.
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