Isavuconazole is used in the treatment of invasive aspergillosis and mucormycosis infections in adults. Isavuconazole disrupts the formation of fungal cell membranes by inhibiting ergosterol biosynthesis. Isavuconazole binds to cytochrome P450 lanosterol 14-α-demethylase encoded by the fungal CYP51 gene, inhibits the activity of 14-α-demethylase, hinders ergosterol synthesis, and the accumulated toxic methylated sterols affect the structural stability and integrity of fungal cell membranes, and change their function, eventually leading to fungal death.
|Appearance||White or pale yellow powder|
|Appearance:||White or pale yellow powder|
|Package details:||10g,100g,1kg/foil bag|
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