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Iron-dextran is an anti-anemia drug. Iron is the main component of hemoglobin and myoglobin. Hemoglobin is the main oxygen carrier in red blood cells. Myoglobin is the site where muscle cells store oxygen for oxygen demand during muscle exercise.
Ferric dextran is a complex of iron and dextran in solution intended for injection. After intramuscular injection, part of the iron is engulfed by macrophages into fibroblasts, and the rest of the iron is slowly removed (about 50% at 72 hours) and transferred to plasma through lymph. Its absorption route is not controlled by the gastrointestinal tract, so the storage of iron is faster and recovers completely. However, hemoglobin still rises at the same rate as oral preparations.
Iron dextran has the advantages of small toxic side effects, stable properties, good solubility and high iron content, and is used as an iron supplement in the pig industry. Clinically, it is often used to determine the cause of chronic blood loss, malnutrition, pregnancy, child development and other iron deficiency anemia.
Items | Specifications | Results |
Appearance | A dark brown colloidal solution | A dark brown colloidal solution |
Identification | Should Conform | Conform |
PH | 4.5~7.0 | 5.94 |
Non Volatile Residue | 45.0%~60.0% | 49% |
Chloride | ≤2.0% | 1.1% |
Limit of phenol | ≤0.5% | 0.45% |
Relative Density | 1.25~1.38 | 1.292 |
Relative Viscosity | ≤30mp.s(25℃) | 18.3mpa.s(25℃) |
Free Iron | ≤0.2% | 0.1% |
Arsenic | ≤4ug per ml | 3ug per ml |
Heavy metal | ≤20ppm | 12ppm |
Bacterial endotoxin | ≤0.50EU/mg Fe | 0.38EU/mg Fe |
Lead | ≤40μg/ml | 29μg/ml |
Copper | ≤60μg/ml | 48μg/ml |
Zinc | ≤150μg/ml | 124μg/ml |
Acute Toxicity | LD50≥500mg Fe per Kg of body weight | Conform |
Iron absorption | The content of unabsorbed iron at the injection site is less than 20% | 13% |
Content of Iron | 190.0mg Fe/ml~210.0mg Fe/ml | 197.8mgFe/ml |
Content of Dextrans | 9.0%~23.0%(g/ml) | 13%(g/ml) |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 9004-66-4 |
| Appearance: | A dark brown colloid solution |
| Purity: | 20% |
| Package details: | 250kg/drum |
| Brand: | Fortunachem |
Uses:
Dihydrostreptomycin Sesquisulfate Salt — Detailed Description
Chemical Identity & Structure
Dihydrostreptomycin sesquisulfate salt is a semi-synthetic aminoglycoside antibiotic derived from streptomycin via catalytic hydrogenation of the aldehyde group at the C-1 position of the streptose sugar moiety. This reduction converts the reactive aldehyde to a primary alcohol, yielding dihydrostreptomycin, which is then formulated as a sulfate salt.
The term "sesquisulfate" denotes the precise stoichiometric ratio: 1.5 moles of sulfuric acid (H₂SO₄) per mole of dihydrostreptomycin base, resulting in the molecular formula (C₂₁H₄₁N₇O₁₂)₂·3H₂SO₄ with a molecular weight of 1461.42 g/mol. The CAS registry number is 5490-27-7.
Structural Features
The molecule contains three sugar units — streptidine, streptose, and N-methyl-L-glucosamine — linked by glycosidic bonds. These multiple amino and hydroxyl groups are responsible for its high polarity, strong hydrogen-bonding capacity, and excellent aqueous solubility. The sulfate counterions provide ionic stabilization and enhance crystallinity.
Physicochemical Properties
| Property | Detail |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Odor | Slight or no characteristic odor |
| Molecular Weight | 1461.42 g/mol |
| Solubility in Water | Very soluble (≥50 mg/mL, up to 100 mg/mL) |
| Solubility in Organic Solvents | Slightly soluble in methanol and ethanol; practically insoluble in acetone, chloroform, and ether |
| pH (10% aqueous solution) | 5.0–7.0 |
| Optical Rotation | [α]D²⁵ = −88.5° (1% w/v aqueous solution) |
| Melting Point | Decomposes before melting (typical of aminoglycoside salts) |
| Hygroscopicity | Hygroscopic — absorbs moisture from air |
| Storage Conditions | 2–8 °C, sealed container, inert atmosphere preferred |
| Potency (Crystalline) | ≥800 µg/mg |
| Potency (Standard Grade) | ≥650 µg/mg |
Mechanism of Action
Dihydrostreptomycin exerts its antibacterial effect by binding irreversibly to the 30S ribosomal subunit, specifically targeting the 16S rRNA component. This binding disrupts bacterial protein synthesis at two critical stages:
Initiation interference — prevents formation of the 70S initiation complex, blocking the start of translation
Elongation disruption — causes misreading of mRNA codons, leading to incorporation of incorrect amino acids and production of non-functional or truncated proteins
The cumulative effect is bactericidal — bacterial cells cannot produce essential proteins and undergo cell death. This mechanism is concentration-dependent, meaning higher drug concentrations achieve faster and more complete bacterial killing.
Spectrum of Activity
Dihydrostreptomycin sesquisulfate exhibits broad-spectrum bactericidal activity against:
Gram-negative bacteria — Escherichia coli, Klebsiella pneumoniae, Proteus spp., Pseudomonas aeruginosa, Salmonella spp., Pasteurella multocida, Brucella spp.
Gram-positive bacteria — Staphylococcus aureus (some strains), Streptococcus spp., Enterococcus spp.
Mycobacteria — Mycobacterium tuberculosis, Mycobacterium bovis
Other pathogens — Yersinia pestis (plague), Francisella tularensis (tularemia), Leptospira spp.
Uses & Applications
Veterinary Medicine (Primary Commercial Use)
This is the dominant application for dihydrostreptomycin sesquisulfate salt:
Cattle — respiratory infections (shipping fever complex), mastitis (intramammary infusion for dry-cow therapy), leptospirosis, and calf septicemia
Pigs — bacterial enteritis, respiratory diseases, and post-weaning infections
Sheep & Goats — pneumonia, foot rot, and systemic bacterial infections
Horses — leptospirosis, strangles, and other susceptible bacterial infections
Poultry — pullorum disease and fowl cholera (in some markets)
Formulated as injectable solutions (e.g., 25% w/v for IM use), oral powders for water medication, intramammary tubes, and boluses
Cell Culture & Biotechnology Research
Used as a supplement in cell culture media (BioReagent grade, ≥95% HPLC purity) to prevent bacterial contamination without affecting mammalian cell growth
Employed in aminoglycoside uptake studies to investigate bacterial membrane transport mechanisms
Used in mechanosensitive channel research and hair-cell bundle electrophysiology studies
Pharmaceutical Reference Standard & Quality Control
Available as a certified reference material traceable to Ph. Eur. and USP pharmacopoeial standards
Used for method development, validation, and quantitative analysis of dihydrostreptomycin in bulk drugs, veterinary formulations, and residue testing in food products
Agricultural Crop Protection
Applied as an antimicrobial agent in certain crop protection programs to control bacterial plant pathogens
Used in seed treatment formulations in some agricultural markets
Historical Human Medicine (Largely Discontinued)
Previously used for tuberculosis treatment and serious infections (plague, tularemia, brucellosis)
Clinical use in humans has been largely abandoned due to a significantly higher risk of irreversible ototoxicity (cochlear damage leading to permanent deafness) compared to streptomycin, which primarily causes vestibular toxicity
Selling Points
Broad-Spectrum Bactericidal Efficacy
Dihydrostreptomycin sesquisulfate delivers concentration-dependent bactericidal activity against a wide range of Gram-negative, Gram-positive, and mycobacterial pathogens. This versatility makes it a reliable first-line antimicrobial in veterinary practice across multiple species and infection types.
Superior Chemical Stability vs. Streptomycin
A critical advantage over the parent compound streptomycin: dihydrostreptomycin is not inactivated by cysteine, hydroxylamine, or semicarbazide, and is resistant to degradation by heating with alkali. This enhanced chemical stability translates to longer shelf life, more robust handling during manufacturing, and greater formulation flexibility.
Excellent Aqueous Solubility
With solubility exceeding 50 mg/mL in water, it dissolves readily for formulation into injectable solutions, oral drinking-water medications, intramammary infusions, and cell culture media — eliminating the need for complex dissolution aids or co-solvents.
Cost-Effective, Mature API
As a well-established, off-patent molecule with decades of manufacturing history, dihydrostreptomycin sesquisulfate is produced at scale through fermentation of Streptomyces griseus followed by extraction, purification, and catalytic hydrogenation. Multiple global suppliers ensure reliable supply chains and competitive pricing — making it economically attractive for large-volume veterinary formulations.
Multiple Pharmaceutical Grades Available
Suppliers offer the product in veterinary bulk grade, BioReagent grade (≥95% HPLC purity), and certified reference material grade — serving diverse customer segments from bulk veterinary drug manufacturers to research laboratories and regulatory testing agencies.
Pharmacopoeia Recognition & Regulatory Clarity
Listed in major pharmacopoeias (USP, Ph. Eur.) with established monographs, defined acceptance criteria, and standardized assay methods. Acceptable Daily Intake (ADI) values have been set by JECFA/WHO, and Maximum Residue Limits (MRLs) are defined for food-producing animals — providing a clear, well-defined regulatory pathway for product registration in global markets.
Established Combination Therapy Potential
Dihydrostreptomycin is frequently combined with penicillin, ampicillin, or tetracyclines in veterinary formulations to achieve synergistic bactericidal effects and broaden the spectrum of coverage — a well-documented combination strategy that adds value for formulators.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Iron-dextran with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Iron-dextran.
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