Ipratropium bromide can be used as a bronchodilator for the maintenance of bronchospasm caused by chronic obstructive pulmonary disease. Ipratropium bromide is a low-fat-soluble quaternary ammonium salt, which is polar, not easy to absorb orally, and can directly act on the airway by nebulized inhalation. Ipratropium bromide is difficult to transport transmembrane into the central nervous system, so there are few systemic adverse effects when administered by inhalation.
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