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Ganglioside GM1 can promote the recovery of nerve function after injury to the central nervous system due to various causes, and its mechanism of action is to promote neural remodeling (including nerve cell survival, axon growth and synapsic production).
Ganglioside GM1 has a protective effect on secondary neurodegeneration after injury, improve cerebral hemodynamic parameters and reduce post-injury cerebral edema, and also improve behavioral disorders caused by Parkinson's disease.
| Item | Specifications | Results |
| Appearance | White or off-white powder | Conform |
| Water | ≤5.0% | 1.0% |
| HPLC purity | Principal peak ≥99.0% | 99.5% |
| Product parameters | |
| Cas number: | 37758-47-7 |
| Appearance: | White or off-white powder |
| Purity: | 99%min |
| Package details: | 100g/bag,1kg/bag or as you require |
| Brand: | Fortunachem |
Ganglioside GM (typically referring to GM1) is a glycolipid naturally found in the membranes of mammalian nerve cells. Clinically, it is primarily used as a prescription drug in the form of Monosialotetrahexosylganglioside (GM1). Its core function is to serve as a neuroprotective agent, providing adjunctive treatment for injuries to the central nervous system (brain and spinal cord).
Definition
Nature: It is a glycolipid component naturally found in cell membranes, particularly abundant in the nervous system .
Source: Clinical formulations are typically extracted from pig brains .
Function: It is involved in the growth, differentiation, and repair of nerve cells .
Clinical Indications
In clinical practice, GM1 is primarily used as an adjunctive treatment for the following conditions :
Central Nervous System (CNS) Injury: Treatment of vascular (e.g., stroke) or traumatic (e.g., brain/spinal cord injury) CNS injuries .
Parkinson's Disease: Used to help improve behavioral disorders and symptoms associated with Parkinson's disease .
Peripheral Neuropathy: Occasionally used for the treatment of peripheral nerve diseases .
Neuroplasticity: It promotes "neuroplasticity," including the survival of nerve cells, axonal growth, and synaptogenesis .
Neuroprotection: It protects against secondary neurodegeneration after injury and reduces nerve cell edema by improving cell membrane enzyme activity .
Blood-Brain Barrier: It has a high affinity for nerve tissue and can cross the blood-brain barrier to reach the site of nerve injury .
Guillain-Barré Syndrome (GBS): There is a serious risk of developing GBS, a condition where the immune system damages nerve cells, causing muscle weakness and paralysis. Patients must be monitored for symptoms like limb weakness or difficulty holding objects .
Controversy & Regulation: While widely used in some regions, its efficacy is debated in international guidelines, and it is strictly monitored due to safety concerns .
Summary: Ganglioside GM is a prescription medication used to aid nerve recovery after brain/spinal injury or for Parkinson's disease, but it carries significant risks and requires strict medical supervision.
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Indication:
▪ Neural Repair
▪ Brain atrophy
▪ Mental disorders
▪ Hypoxic ischemic encephalopathy
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