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Cloxacillin benzathine is a broad-spectrum antibiotic that is effective in treating infections caused by Staphylococcus and streptococcus because it absorbs well and rapidly in the intestine, is not disturbed by food, has a high blood concentration, and lasts for a long time.
Cloxacillin benzathine is a long-acting, injectable formulation combining cloxacillin (a penicillinase-resistant β-lactam antibiotic) with benzathine (a diamine salt that slows absorption). Here's a concise overview:
Purpose:
Prolongs cloxacillin's release, maintaining therapeutic blood levels for days.
Targets penicillinase-producing Staphylococci (e.g., Staphylococcus aureus).
Uses:
Treats/resists bacterial infections (e.g., skin/soft tissue, mastitis in livestock).
Often used in veterinary medicine for sustained action.
Administration:
Intramuscular (IM) injection to ensure slow absorption.
Advantages:
Reduces dosing frequency vs. short-acting cloxacillin (e.g., sodium salt).
Safety:
Contraindicated in penicillin-allergic individuals.
Potential injection-site reactions (pain, swelling).
Cloxacillin: Inhibits bacterial cell wall synthesis.
Benzathine: Delays drug breakdown, extending efficacy.
While benzathine is common with penicillin G (e.g., Bicillin® for syphilis), cloxacillin benzathine is niche, primarily in veterinary contexts. Always confirm local guidelines for approved uses.
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