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Clindamycin hydrochloride can effectively kill staphylococcus, anaerobic bacteria, pneumococci and streptococci. It has an active effect on pathogenic parasites such as Pneumocysticercus, Toxoplasma gondii and Plasmodium falciparum, and has few adverse effects. Clindamycin hydrochloride is a derivative of lincomycin, and the antibacterial spectrum of clindamycin hydrochloride is broader than that of lincomycin, and the antibacterial activity is 4-8 times higher than that of lincomycin. It has antibacterial activity against gram-positive aerobes, staphylococci and streptococci, and also has antibacterial activity against mycoplasma, chlamydia and a variety of anaerobic bacteria.
Clindamycin hydrochloride is mainly used to treat infections caused by gram-positive cocci and various anaerobic bacteria; it is mainly used to treat joint, bone marrow, respiratory tract and skin soft tissue infections, as well as tonsillitis, pharyngitis, pneumonia, acne, gynecological inflammation, endocarditis, empyema.
Items | Specifications | Results |
Appearance | A White or almost white,crystalline powder | White crystalline powder |
Identification | A:The retention time of the major peak of the Samplesolution corresponds to that of the Standard solution,as obtained in the Assay. B.Infrared Absorption | Conform Conform |
Crystallinity | Meets the requirements | Conform |
Acidity | Ph 3.0~5.5 | 4.4 |
Related compounds | Clindamycin B≤2.0% 7-epiclindamycin≤4.0% Other individual related compound≤1.0% Total of all related compounds≤6.0% | 0.68% 0.47% 0.19% 1.8% |
Water | 3.0%~6.0% | 3.8% |
Residue on ignition | ≤0.5% | 0.02% |
Bulk density | --- | 0.41g/cm3 |
Tapped density | --- | 0.56g/cm3 |
Residual solvents | Ethanol≤0.5% Acetone≤0.5% Chloroform≤0.006% N,N-Dimethylformamide≤0.088% | None detected 0.023% None detected None detected |
Assay | Not less than 800μg/mg | 875μg/mg |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 21462-39-5 |
| Appearance: | White crystalline powder |
| Purity: | ≥800ug/mg |
| Package details: | 1kg/foil bag; 25kg/drum |
| Brand: | Fortunachem |
Clindamycin hydrochloride is a salt form of clindamycin, a lincosamide antibiotic. It is a semi-synthetic derivative of lincomycin, designed for better absorption and bioavailability, primarily formulated for oral administration (capsules, oral solution).
Bacteriostatic: It inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome.
Effective against aerobic gram-positive cocci and, critically, many anaerobic bacteria (both gram-positive and gram-negative).
Due to its excellent tissue penetration and anaerobic coverage, it is prescribed for:
Serious Anaerobic Infections: Especially below the diaphragm (e.g., intra-abdominal abscesses, peritonitis, endometritis).
Skin and Soft Tissue Infections: Caused by Staphylococcus aureus (including some MRSA strains) and streptococci.
Bone and Joint Infections: Particularly osteomyelitis caused by susceptible organisms.
Oral Infections: Used in dentistry for severe dental abscesses involving anaerobes.
Alternative to Penicillin: For patients with severe penicillin allergy, in conditions like tonsillitis or cellulitis.
Adjunct Therapy: Used with other drugs for infections like pelvic inflammatory disease (PID) or toxoplasmosis.
Clostridioides difficile-Associated Diarrhea (CDAD): Its use significantly disrupts normal gut flora and is a major cause of severe, potentially life-threatening C. diff colitis. Use is reserved for cases where benefits outweigh this serious risk.
| Feature | Clindamycin Hydrochloride |
|---|---|
| Drug Class | Lincosamide antibiotic (bacteriostatic) |
| Key Strength | Excellent anaerobic and gram-positive coverage |
| Common Forms | Oral capsules, oral solution |
| Main Uses | Anaerobic infections, skin/soft tissue infections, bone infections, dental abscesses, penicillin-allergy alternative |
| Critical Risk | High association with C. diff colitis—must be used judiciously. |
| Note | Other clindamycin salts (e.g., phosphate) are used for topical or injectable formulations. |
Disclaimer: This is a prescription-only antibiotic. Its use requires a confirmed or strongly suspected bacterial infection susceptible to clindamycin, as misuse contributes to resistance and serious adverse effects. Always complete the prescribed course.
Antibacterial, inhibits protein synthesis.
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