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Vitamin E-TPGS (Tocofersolan) is a water-soluble derivative of natural Vitamin E, created by combining Vitamin E with PEG. Its unique amphiphilic structure allows it to mix oil and water seamlessly.
Key selling points include:
Superior Solubility: It dissolves easily in water, making it perfect for people with fat malabsorption issues.
Absorption Booster: It significantly enhances the bioavailability of poorly soluble drugs and nutrients.
Fights Drug Resistance: It inhibits the P-gp protein, preventing cells from pumping out medications like chemotherapy drugs, thereby increasing treatment efficacy.
Antioxidant Stability: It protects formulations from oxidation.
Approved by the FDA and EFSA, it is a safe, versatile excipient widely used in pharmaceuticals and nutrition.
Items | Specifications | Results |
Appearance (25℃) | white to light yellow waxy solid | Conforms |
Identification | Meets the requirements | Conforms |
（D-α-tocopherol）Assay | ≥26.0% | 29.3% |
Monoesterified Polyethylene glycol | ≥80.0% | 89.1% |
Polyethylene Glycol | ≤10.0% | 6.1% |
Vitamin E | ≤1.5% | Not Detected |
Vitamin E Succinate | ≤0.2% | Not Detected |
Solubility in water | 20% Min (Clear solution within 3h) | Conforms |
Acidity | ≤0.27ml | 0.13ml |
Specific Rotation | ≥+24.0° | +26.2° |
Heavy metals | ≤10ppm | < 10ppm |
Residual solvents: Ethanol Ethyl acetate |
≤200ppm ≤50ppm |
5ppm Not Detected |
Microbe. Test: Total Plate Count Yeast & Mold Salmonella E.Coli |
≤1000CFU/g ≤100CFU/g Negative Negative |
< 10CFU/g < 10CFU/g Negative Negative |
Conclusion | The product conforms to the above specifications. | |
Vitamin E-TPGS (also known as Tocofersolan) is a special water-soluble derivative of natural Vitamin E.
Chemically, it is created by connecting natural Vitamin E (D-α-Tocopherol) with Polyethylene Glycol (PEG) using succinic acid. This unique structure gives it two distinct parts:
A lipophilic (fat-loving) tail from the Vitamin E.
A hydrophilic (water-loving) head from the PEG chain.
Because of this "amphiphilic" (dual-nature) structure, it acts as a powerful non-ionic surfactant, meaning it can easily mix oil and water.
Key Selling Points of Vitamin E-TPGS
Vitamin E-TPGS is highly valued in the pharmaceutical, nutraceutical, and cosmetic industries. Here are its main selling points:
1. Superior Water Solubility & Absorption
Unlike regular Vitamin E, which is fat-soluble and requires bile and dietary fats to be absorbed (often with only 20-40% absorption rates), TPGS dissolves easily in water. It can form tiny structures called "micelles" that encapsulate fat-soluble compounds, allowing them to pass through the intestinal wall effortlessly. This makes it an excellent nutrient source for people with fat malabsorption issues (such as those with cystic fibrosis or liver diseases).
2. Powerful Bioavailability Enhancer
TPGS is widely used as a high-performance excipient (inactive ingredient) in drug formulations. It significantly boosts the absorption of poorly soluble drugs and nutrients (like CoQ10, curcumin, or certain cancer drugs) by increasing their solubility and helping them cross cell membranes.
3. Overcomes Drug Resistance (P-gp Inhibitor)
One of its most unique medical selling points is its ability to inhibit P-glycoprotein (P-gp). P-gp is a protein in our cells that often pumps foreign substances (like chemotherapy drugs) back out, causing drug resistance. TPGS blocks this "efflux pump," keeping the medicine inside the cells longer and making treatments—especially cancer therapies—much more effective.
4. Strong Antioxidant & Stability
TPGS retains the natural antioxidant properties of Vitamin E, protecting cells from oxidative stress and free radical damage. Additionally, its antioxidant nature helps stabilize formulations, preventing other sensitive ingredients in a product from degrading quickly.
5. Versatile & Safe
Multi-functional: It acts as an emulsifier, solubilizer, absorption enhancer, and even a plasticizer in various products.
Safety Approved: It is approved as a safe pharmaceutical excipient and food additive by major global regulatory bodies, including the US FDA and the European EFSA.
Quick Comparison: Regular Vitamin E vs. Vitamin E-TPGS
| Feature | Regular Vitamin E (Tocopherol) | Vitamin E-TPGS (Tocofersolan) |
| Solubility | Fat-soluble (needs dietary fat) | Water-soluble (dissolves in water) |
| Absorption | Requires bile salts; lower absorption rate | Self-emulsifying; highly efficient absorption |
| Primary Use | General antioxidant supplement | Drug delivery, enhancing absorption, overcoming resistance |
| Structure | Simple lipophilic molecule | Complex amphiphilic structure (surfactant) |
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Azaperone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Azaperone.
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