Ambroxol hydrochloride mainly acts on respiratory secretory cells, regulates the secretion of mucous and serous substances, increases serous secretion, and can also lyse polysaccharide fibers of acid glycoproteins in sputum, inhibit the synthesis of acidic proteins in mucous glands and goblet cells, reduce the viscosity of sputum, make sputum thin and easy to discharge; At the same time, the drug can also increase the movement frequency and intensity of respiratory cilia, promote sputum discharge and respiratory self-purification effect.
Ambroxol hydrochloride has a pronounced antioxidant effect and plays an important role in lung disease lesions of reactive free oxygen groups. Studies have shown that ambroxol has a strong inhibitory effect on H2O2 produced by neutrophils; In addition, ambroxol activates the intracellular glutathione system and promotes the synthesis of intracellular glutathione (GSH), thereby countering the damaging effects of oxygen free radicals.
Ambroxol hydrochloride is a new generation of mucosal sputum dissolving agents that improve sputum expulsion and have the effect of promoting pulmonary surfactant and airway secretion and ciliary movement. Ambroxol hydrochloride is widely used in acute and chronic respiratory diseases with abnormal respiratory secretion, especially the expectorant treatment of chronic bronchitis, neonatal respiratory distress, and adjuvant treatment of lung surgery. It has the advantages of low toxicity, accurate efficacy, and can be used with antibiotics to produce good synergistic effects, and is one of the most commonly used expectorants.
|Appearance||White or yellowish crystalline powder||Conforms|
|Loss on drying||≤0.5%||0.06%|
(on dried basis)
|Appearance:||White or yellowish crystalline powder|
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