Name: China Factory Supply High Quality Amiodarone hydrochloride CAS 19774-82-4
Brand: Wuhan Fortuna Chemical Co., Ltd.

Items	Specifications	Results
Appearance	White or almost white,fine, crystalline powder	Almost white,fine,crystalline powder
Solubility	Very slightly soluble in water, freely soluble in methylene chloride,soluble in methanol, sparingly soluble in ethanol (96 percent).	Very slightly soluble in water, freely soluble in methylene chloride,soluble in methanol, sparingly soluble in ethanol (96 percent).
Identification	A)IR :Conforms to Amiodarone Hydrochloride CRS	Conforms
Identification	B)Chlorides :It gives reaction of chlorides	Conforms
Appearance of Solution	The solution is clear	Clear
Appearance of Solution	Not more than GY₅or BY₅	Less than GY₅
PH	3.2 to 3.8	3.5
Loss on Drying	≤0.5%	0.04%
Sulphated Ash	≤0.1%	0.03%
Iodides	≤150 ppm	<150 ppm
Impurity H	≤0.02%	<0.02%
Related Substances	Impurity A: ≤0.2%	≤0.01%
	Impurity B: ≤0.2%	0.04%
	Impurity C: ≤0.2%	<0.01%
	Impurity D: ≤0.2%	<0.01%
	Impurity E: ≤0.2%	<0.01%
	Impurity F: ≤0.2%	<0.01%
	Impurity G: ≤0.2%	<0.01%
	Unspecified Impurities: ≤0.10%	0.02%
	Total Impurities: ≤0.5%	0.07%
Ethanol	≤5000 ppm	502 ppm
Toluene	≤890 ppm	<80 ppm
Assay	98.5%to 101.0%(dried substance)	100.7%
Conclusion	The product conforms to the above specifications.

Amiodarone hydrochloride is the hydrochloride salt form of amiodarone, a potent Class III antiarrhythmic medication. It is used primarily to treat and prevent serious, life-threatening cardiac arrhythmias (irregular heartbeats).

Primary Uses:

It is indicated for ventricular and supraventricular arrhythmias that are recurrent or resistant to other therapies, including:

Ventricular Fibrillation (VF) & Ventricular Tachycardia (VT): Especially for prevention in high-risk patients.
Atrial Fibrillation (AF) and Flutter: To maintain normal sinus rhythm (chemical cardioversion and long-term maintenance).
Other Supraventricular Tachycardias (SVTs): When standard treatments are ineffective or contraindicated.

Key Characteristics & Administration:

Mechanism: It works primarily by prolonging the cardiac action potential and refractory period (Class III effect), but also has Class I, II, and IV properties, making it a very broad-spectrum antiarrhythmic.
Administration:

Intravenous (IV): Used in hospital settings for acute, life-threatening arrhythmias.
Oral: Used for long-term maintenance therapy.

Notable Properties: It has an exceptionally long half-life (up to several weeks), requiring a loading dose regimen. It also has significant lipophilicity (fat solubility).

Important Safety Notes (Major Side Effects):

Due to its potency, amiodarone has a high risk of serious, sometimes irreversible side effects, necessitating careful patient monitoring. Major concerns include:

Pulmonary Toxicity: Interstitial pneumonitis, which can be fatal.
Thyroid Dysfunction: Can cause both hypothyroidism and hyperthyroidism.
Hepatotoxicity: Liver enzyme elevations and, rarely, hepatitis.
Cardiac Effects: Can paradoxically cause bradycardia (slow heart rate) and, rarely, worsen arrhythmias.
Other: Skin photosensitivity (blue-grey discoloration), corneal microdeposits, and neuropathic effects.

In summary, amiodarone hydrochloride is a highly effective but potentially toxic "drug of last resort" for managing severe cardiac arrhythmias, reserved for cases where the benefits outweigh its significant risks. Its use requires careful ongoing clinical and laboratory monitoring.