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L-Norvaline is a non-proteinogenic amino acid (C₅H₁₁NO₂) with a straight propyl side chain, structurally similar to valine but lacking its branched group. It is primarily used in biochemical research as an inhibitor of nitric oxide synthase (NOS) and arginase, helping study cardiovascular and immune pathways. It has appeared in some dietary supplements claiming to enhance blood flow or athletic performance, though its safety is questionable—linked to potential neurotoxicity and metabolic disruption. L-Norvaline also serves as a chiral building block in peptide synthesis and drug development. Additionally, it’s used in microbiology to investigate bacterial metabolism. Importantly, it is not used by the body to build proteins, and accumulation may interfere with normal amino acid function. Due to health concerns, regulatory agencies caution against its uncontrolled use in consumer products. Handle only in controlled research settings.
Items | Specifications | Results |
Appearance | White crystals or crystalline powder | Conforms |
Specific rotation [α]D20 | +23.0°~+25.0° | +24.3° |
State of solution | ≥98.0% | 99.1% |
pH | 5.6~6.5 | 6.0 |
Chloride(Cl) | ≤0.02% | <0.02% |
Sulfate(SO4) | ≤0.02% | <0.02% |
Heavy metals(Pb) | ≤10ppm | <10ppm |
Arsenic(As2O3) | ≤1ppm | <1ppm |
Loss on drying | ≤0.50% | 0.11% |
Residue on ignition | ≤0.10% | 0.04% |
D-Norvaline | ≤0.1% | N.D |
L-Valine | ≤0.1% | N.D |
L-Leucine | ≤0.1% | N.D |
L-Norleucine | ≤0.1% | N.D |
Assay | 98.5~101.0% | 99.2% |
Conclusion | The product conforms to the above specifications. | |
L-Norvaline is a non-proteinogenic (non-standard) amino acid with the chemical formula C₅H₁₁NO₂. Structurally, it resembles the protein-building amino acid L-valine, but it has a shorter side chain: instead of an isopropyl group, L-norvaline has a simple n-propyl group (–CH₂CH₂CH₃). It is the L-enantiomer of norvaline, meaning it has the same stereochemistry as natural amino acids used in biology.
Key Uses:
Pharmaceutical & Biochemical Research:
Used to study enzyme specificity, especially in amino acid-metabolizing enzymes like arginase or nitric oxide synthase (NOS).
Acts as an inhibitor of certain NOS isoforms, helping researchers investigate nitric oxide pathways involved in inflammation and blood pressure regulation.
Dietary Supplements (Controversial):
Sometimes added to pre-workout supplements under the claim of boosting nitric oxide and improving blood flow.
However, its safety is debated—some studies link it to toxicity or interference with normal amino acid metabolism.
Chemical Synthesis:
Serves as a chiral building block for synthesizing peptides, antibiotics, and other bioactive molecules.
Microbiology:
Used in culture media to study bacterial metabolism or antibiotic resistance mechanisms.
⚠️ Note: L-Norvaline is not incorporated into human proteins and may disrupt normal cellular processes if accumulated. Regulatory agencies have raised concerns about its use in supplements due to potential neurotoxic or metabolic effects.
In summary, L-norvaline is mainly a research tool with limited therapeutic application and significant safety considerations.
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