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N-Acetyl-L-tryptophan (CAS 1218-34-4, C₁₃H₁₄N₂O₃, MW 246.26) is the Nα-acetylated L-tryptophan derivative: a white to off-white crystalline powder, sparingly soluble in cold water, soluble in hot water/ethanol/dilute alkali, stored sealed and protected from light (the indole oxidizes to yellow/pink). Main uses: (1) a classic HSA/chiral-column probe solute for characterizing Sudlow site II and protein-binding displacement; (2) an LC-MS metabolomics standard for the tryptophan–kynurenine pathway (IDO/TDO, gut–brain axis); (3) the DL form as an aminoacylase substrate for enzymatic resolution; (4) a prodrug and albumin-binding ligand handle to extend half-life in drug design; (5) peptide and indole intermediate. Selling points: dual-function acetyl cap plus indole, well-defined chirality (ee ≥99%), one-step synthesis from commodity L-tryptophan, gram-scale high value density, full CoA/NMR/optical-rotation docs, and cross-sell with 5-HTP, melatonin, kynurenine and the N-acetyl amino acid series. RUO / further-manufacturing use only.
Specifications of N-Acetyl-L-tryptophan CAS 1218-34-4 COA:
Items | Specifications | Results |
Appearance | White to off-white powder | Conform |
Purity(HPLC) | ≥98% | 99.7% |
Assay | 98.0%~102.0% | 98.8% |
Specific Rotation | +25.8°~+27.0° | +26.3° |
Loss on drying | ≤1.0% | 0.54% |
Conclusion | The product conforms to the above specifications. | |
Product Name:N-Acetyl-L-tryptophan
CAS:1218-34-4
MF:C13H14N2O3
Melting point :186°C
form:powder
color:White to off-white
Uses:
| Item | Details |
|---|---|
| Common names | N-Acetyl-L-tryptophan; NATA; Nα-Acetyl-L-Trp; Ac-L-Trp-OH |
| CAS | 1218-34-4（L型）；D型 2950-03-4；DL型 87-32-1 |
| IUPAC | (2S)-2-acetamido-3-(1H-indol-3-yl)propanoic acid |
| Formula / MW | C₁₃H₁₄N₂O₃ / 246.26 |
| Appearance | White to off-white crystalline powder (indole tends to yellow/pink on light exposure) |
| Melting point | ~205–209 °C (dec.) |
| Optical rotation | [α]D ≈ −20 to −24° (c≈1, EtOH) — key chirality check |
| pKa | ~3.4 (COOH); indole NH very weakly acidic (pKa ~16–17) |
| Solubility | Slightly soluble in cold water; soluble in hot water, ethanol, alkali; sparingly soluble in most organics |
| Storage | Sealed, dry, 2–8 °C or cool dark place; protect from light & oxidizers |
| HS code | 2933.99 / 3824 (check locally) |
It is the Nα-acetylated derivative of L-tryptophan: an acetamide cap on the α-amino group plus a free carboxyl, with an indole side chain. Made simply by acetylating L-tryptophan (acetic anhydride/acetyl chloride in base), so it's cheap and scalable. The acetyl group blocks the amine (no zwitterion, lower polarity, no unwanted N-acylation), while the indole remains available for π-stacking, H-bonding and strong binding to serum albumin (Sudlow site II).
2. Main uses
① Analytical chemistry — HPLC column & HSA binding probe (classic use)
NAT is a textbook marker solute for human serum albumin (HSA) immobilized/chiral columns, probing the indole-binding (Sudlow site II) pocket. It's used to characterize stationary phases, test enantioselectivity, measure drug–protein binding displacement, and as a system-suitability/test solute in method development.
② Biochemical & metabolomics reference standard
N-Acetyltryptophan is an endogenous tryptophan metabolite (found in urine/plasma, partly from gut microbial/aromatic amine metabolism). It serves as a quantitative standard in LC-MS metabolomics panels covering the tryptophan–kynurenine–serotonin–melatonin axis, IDO/TDO activity studies, gut–brain axis and nutritional research.
③ Enzymatic resolution substrate (as the DL form)
N-Acetyl-DL-tryptophan is a standard substrate for aminoacylase I in industrial enzymatic resolution to produce L-tryptophan and resolve DL-amino acids — a steady biocatalysis demand.
④ Prodrug & drug-design building block
The free COOH can be esterified with hydroxyl-containing drugs to make acyl prodrugs that raise lipophilicity and mask charge.
The indole/acetyl-Trp motif is a well-known albumin-binding ligand; attaching it (or its esters/amides) is a route to extend peptide/small-molecule half-life via reversible albumin association — a recurring medicinal-chemistry tactic.
N-acetyl capping mimics an acetylated N-terminus in peptide mimetics; also used to block Trp in SAR scans.
⑤ Peptide & fine-chemical intermediate
Used where an Ac-Trp residue is needed without on-residue acetylation steps; precursor to indole-containing amides, esters and heterocycles.
⑥ Cosmetics / nutrition (minor, claim-sensitive)
Tryptophan derivatives are explored as antioxidant/soothing and UV-related ingredients; L-tryptophan itself is a dietary supplement. NAT here is a niche ingredient — any function must follow local cosmetic filing and avoid medical claims.
3. Selling points
Performance / application
Dual-function structure: acetyl cap tunes polarity/stability + indole gives strong, specific albumin/π interactions — useful in both analysis and drug design.
Chiral, well-defined single entity: clean ¹H-NMR, sharp HPLC peak, reliable optical rotation → ideal as a reference material.
Low dose, high value in analytics: mg–g reference standards command strong margins; small packs, low freight.
Supply-side
4. Simple, cheap synthesis from commodity L-tryptophan: one acetylation + crystallization; easy to scale and to keep cost stable.
5. Grade ladder: research/analytical standard grade → pharma-intermediate grade → (where documented) food/cosmetic-grade; offer ee ≥99%, assay ≥98–99%, low related substances, low residual acetate/anhydride, controlled color (indole discoloration) and heavy metals.
6. Full doc pack: CoA, HPLC/GC, NMR, MS, optical rotation, chiral report, SDS, residual solvent, TSE/BSE-free, non-GMO, origin statement.
7. Portfolio cross-sell: L-tryptophan, 5-HTP, melatonin, serotonin, kynurenine, N-acetyl-DL-Trp, N-acetyl-L-tyrosine, N-acetyl amino acid series, Fmoc/Boc-Trp, HSA columns & other probe solutes — one inquiry becomes several SKUs.
8. Easy logistics: non-volatile solid, ambient-to-cool storage, long shelf life, no cold chain required for short transit.
4. Risks worth disclosing
Light/oxidation sensitivity: indole oxidizes → yellow/pink discoloration and new impurities. Pack in amber/PE-lined containers with desiccant, protect from light, and define a retest period.
Solubility: poor in cold water and many organics; dissolve in warm water/ethanol or dilute alkali/DMSO.
Handling: irritant (typical H315/H319/H335); avoid dust; keep away from strong oxidizers.
Market reality: not a bulk commodity — demand is fragmented across analytics, research and niche intermediates; competition from catalog reagent makers is stiff. Margin lives in documentation, chiral proof and breadth of the Trp family, not price alone.
Compliance boundary: RUO / "for further manufacturing or research use only"; do not carry over food/pharma claims from other grades; cosmetic use only per filed functions.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide N-Acetyl-L-tryptophan with good quality and best price, welcome to contact us to get COA/TDS/MSDS of N-Acetyl-L-tryptophan.
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