Name: Chemical Manufacturer Supply High Quality Best Price Betamethasone 17,21-dipropionate CAS 5593-20-4 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Detailed Description

Specifications of Betamethasone 17,21-dipropionate CAS 5593-20-4 COA:

Items	Specifications	Results
Appearance	White or almost white crystalline powder.	Almost white crystalline powder
Solubility	Practically insoluble in water,freely soluble in acetone and in methylene chloride,sparingly soluble in ethanol	Complies
Identification(IR,TLC)	Complies with the Standard	Complies
Specific rotation(In dioxane)	+63°~+70°	+67.6°
Loss on drying	Not more than 1.0%	0.22%
Residue on ignition	Not more than 0.2%	0.08%
Related substances(HPLC)
Single impurity	Not more than 1.0%	0.49%
Sum impurities	Not more than 2.0%	0.98%
Assay(HPLC,basis on drying)	97.0%~103.0%	99.8%
Residual solvents
Acetone	Not more than 5000ppm	Complies
Methanol	Not more than 3000ppm	Complies
Dichloromethane	Not more than 600ppm	Complies
THF	Not more than 720ppm	Complies
Pyridine	Not more than 200ppm	Complies
Packaging and storage	Preserve in tight,light-resistant containers.
Conclusion	The product conforms to the above specifications.

Product Name:Betamethasone 17,21-dipropionate

CAS:5593-20-4

MF:C28H37FO7

Melting point :178 °C
form:Crystalline powder
color:Almost White
Uses:

Betamethasone 17,21-Dipropionate

Betamethasone 17,21-dipropionate (CAS 5593-20-4) is a synthetic fluorinated glucocorticoid — the 17,21-dipropionate ester of betamethasone. It is a white to creamy-white, odorless crystalline powder with the molecular formula C₂₈H₃₇FO₇ and molecular weight of 504.59 g/mol. It is practically insoluble in water, freely soluble in acetone and chloroform, and sparingly soluble in ethanol.

It is classified as a Class III potent topical corticosteroid with strong anti-inflammatory, anti-pruritic, immunosuppressive, and vasoconstrictive properties.

Mechanism of Action

It binds to intracellular glucocorticoid receptors, and the receptor-ligand complex translocates to the nucleus to modulate gene expression — inducing anti-inflammatory proteins and suppressing inflammatory mediators, thereby reducing chronic inflammation and autoimmune responses.

Uses & Applications

Topical Dermatology (Primary Use)

The most widespread application is as a topical corticosteroid (typically 0.05% cream, ointment, lotion, or gel) for treating corticosteroid-responsive dermatoses, including:

Eczema & dermatitis — atopic eczema, contact dermatitis, photodermatitis

Psoriasis — scalp psoriasis, chronic plaque psoriasis of hands and feet

Lichen planus & lichen simplex

Prurigo nodularis

Discoid lupus erythematosus

Seborrheic dermatitis & chronic hand eczema

Neurodermatitis

Injectable Formulations

In compound betamethasone injection (e.g., Diprophos), it is combined with betamethasone sodium phosphate to provide both rapid-onset and sustained-release glucocorticoid effects for:

Musculoskeletal diseases — rheumatoid arthritis, osteoarthritis, bursitis, ankylosing spondylitis, epicondylitis

Allergic diseases — chronic bronchial asthma, allergic rhinitis, angioedema, serum sickness

Autoimmune conditions — systemic lupus erythematosus

Dermatological conditions — alopecia areata, pemphigus, keloids, cystic acne

Tumor palliation — adult leukemia and lymphoma

Combination Products

It is formulated in combination with other active ingredients for enhanced efficacy:

Calcipotriol + betamethasone dipropionate (e.g., Daivobet/Dovobet) — for psoriasis vulgaris

Betamethasone dipropionate + salicylic acid (e.g., Diprosalic) — for hyperkeratotic dermatoses

Betamethasone dipropionate + clotrimazole + gentamicin — for secondarily infected dermatoses

Tazarotene + betamethasone dipropionate — for psoriasis

Research & Analytical Use

Used as a reference standard and research compound in pharmaceutical quality control and pharmacological studies.

Selling Points

High Potency with Broad Indications

As a Class III potent corticosteroid, it delivers rapid and sustained anti-inflammatory, anti-pruritic, and vasoconstrictive effects across a remarkably wide range of dermatological, musculoskeletal, allergic, and autoimmune conditions — making it one of the most versatile glucocorticoid APIs available.

Multiple Dosage Forms

Available as creams, ointments, lotions, gels, foams, and injectable suspensions — enabling tailored treatment for different body areas, severity levels, and patient preferences. This formulation flexibility is a major commercial advantage.

Proven Clinical Track Record

First approved in the U.S. in 1983, it has over 40 years of clinical use with extensive real-world evidence supporting its efficacy and safety profile. Branded products like Diprolene, Diprosone, and Diprosalic are globally recognized.

Strong Market Demand

Multiple dosage forms are listed on national medical insurance catalogs. In China alone, the domestic market exceeded ¥300 million in 2023, with growing demand driven by aging populations and rising prevalence of chronic inflammatory skin conditions.

Well-Established Combination Therapies

Its successful pairing with calcipotriol (for psoriasis), salicylic acid (for hyperkeratotic conditions), and antifungals/antibiotics (for infected dermatoses) creates high-value combination products with premium pricing potential.

Patent-Free / Generic-Friendly

The original patents have expired, opening significant opportunities for generic manufacturing and API supply in both regulated and emerging markets.

Favorable Safety at Recommended Doses

When used as directed (≤50 g/week, ≤2 weeks continuous), the steroid content per tube is low enough to pose minimal systemic toxicity risk, with reversible HPA axis suppression being the primary concern — manageable through proper clinical monitoring.

Dual-Release Injection Technology

In compound injection form, the combination of soluble betamethasone sodium phosphate (rapid onset) + microcrystalline betamethasone dipropionate (sustained depot release) provides both immediate relief and prolonged symptom control from a single injection — a unique therapeutic advantage.

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Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd

Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.

Q6: How do you treat quality complaint ?

A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.

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Company Information

Name:Wuhan Fortuna Chemical Co.,Ltd

Category:Others

Trade Category: Trading Company

Employees: 11 - 50 People

Address: Room 2015, No.2 Building, Kaixin Mansion No.107

Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.

Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.

We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.

Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.

Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Betamethasone 17,21-dipropionate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Betamethasone 17,21-dipropionate.

Our Advantages:

1. Guaranteed purity;

2. Large quantity in stock;

3. Largest manufacturer;

4. Best service after shipment with email;

5. High quality & competitive price;

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