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Calcium glycerophosphate is a nutritional supplement, a calcium enhancer for foods, and a stabilizer. Calcium glycerophosphate is used in baby food, bread, baking powder, wheat flour, etc.
Calcium glycerophosphate used in food can play the role of calcium supplement; In medicine, it plays the biological and physiological role of calcium, has the function of perfecting tissue cells and constituting bone tissue, and at the same time plays the role of calcium glycerophosphate salt metabolism, and has the effect of supplementing brain vitality.
Specifications of Calcium Glycerophosphate CAS 27214-00-2 COA:
Items | Specifications | Results |
Appearance | White powder,hygroscopic,sparingly soluble in water,practically insoluble in alcohol. | White powder,hygroscopic,sparingly soluble in water,practically insoluble in alcohol. |
Identification | Should assume correctitude reaction | Assume correctitude reaction |
Acidity or Alkalinity | ≤1.7ml | 0.2ml |
Glycerin and alcohol-solube substance | ≤10mg | 1mg |
Chloride | ≤0.2% | ＜0.2% |
Sulphates | ≤0.5% | ＜0.5% |
Other glycerol phosphates | ≥7.5ml | 8.1ml |
Phosphates | ≤0.04% | ＜0.04% |
Loss on drying | ≤15.0% | 10.8% |
Residue on ignition | 43~49% | 47% |
Heavy Metal | ≤ 20 ppm | ＜20ppm |
Arsenic | ≤5ppm | ＜5ppm |
Ethanol | ≤0.5% | ＜0.1% |
Mixed bacterium counts | ≤1000cfu/g | ＜10cfu/g |
Mildew and microzyme counts | ≤100cfu/g | ＜10cfu/g |
Escherichia coli | No Colibacillus | No |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 27214-00-2 |
| Appearance: | White or light yellow powder |
| Purity: | 95% min |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Uses:
| Property | Detail |
|---|---|
| CAS Number | 27214-00-2 (also 58409-70-4) |
| Molecular Formula | C₃H₇CaO₆P |
| Molecular Weight | 210.14 g/mol |
| EINECS Number | 248-328-5 |
| Calcium Content | 18.6%–19.4% (on dried basis) |
| Appearance | White to off-white crystalline powder |
| Odor/Taste | Odorless or nearly so; slightly bitter |
| Solubility | Slightly soluble in water (~1 g per 50 mL at 25 °C); more soluble in cold water than hot; soluble in glycerol and propylene glycol; insoluble in ethanol |
| Aqueous pH | Alkaline |
| Thermal Stability | Loses crystal water at 130 °C; decomposes above 170 °C |
| Density | 1.82–1.855 g/cm³ (at 20 °C) |
| FDA Status | GRAS (Generally Recognized As Safe) as a nutrient supplement |
| Trade Names | Prelief, Cacit, Neurosin, NutriGP |
| Isomer Composition | Typically ~80% β-isomer and ~20% rac-α-isomer |
Core Uses & Applications
1. Dietary Supplement & Bone Health — The Primary Application
Calcium Glycerophosphate is widely used as a highly bioavailable source of both calcium and phosphorus in dietary supplements. Unlike inorganic calcium salts (e.g., calcium carbonate, calcium phosphate), CaGP delivers both essential bone-building minerals in a single, readily absorbable organic complex.
Key advantages over conventional calcium supplements:
Superior bioavailability — the organic glycerophosphate structure enhances intestinal absorption compared to less soluble inorganic calcium salts
Dual-mineral delivery — provides both Ca²⁺ and phosphate in one compound, supporting the formation of hydroxyapatite (the primary mineral component of bones and teeth)
Gentle on the GI tract — less likely to cause constipation or bloating compared to calcium carbonate
Alkaline-buffering action — neutralizes excess stomach acid, providing relief from heartburn and acid reflux simultaneously
Clinical relevance:
Prevention and management of osteoporosis and osteopenia
Treatment of calcium deficiency (hypocalcemia)
Support for bone health in aging populations, postmenopausal women, and growing children
Investigated for rickets and osteomalacia
2. Dental & Oral Care — Cariostatic & Remineralizing Agent
Since the 1960s, CaGP has been recognized for its anti-caries (anti-tooth-decay) properties. It is incorporated into toothpastes, mouthwashes, and dental care products as a functional active ingredient.
Mechanisms of action in oral care:
Plaque pH buffering — neutralizes acid produced by cariogenic bacteria, reducing enamel demineralization
Elevation of plaque calcium and phosphate levels — creates a mineral-rich environment that favors remineralization over demineralization
Direct interaction with dental mineral — enhances acid resistance of tooth enamel and promotes enamel mineralization
Synergy with fluoride — clinical studies show that CaGP combined with sodium monofluorophosphate (SMFP) produces superior anti-caries effects compared to SMFP alone
Recent research has also demonstrated that incorporating nano-sized β-calcium glycerophosphate into toothpaste formulations significantly increases enamel surface hardness and calcium/phosphate bioavailability compared to standard formulations.
3. Food & Beverage Industry — Nutritional Fortification
CaGP is used as a food-grade calcium fortifier and nutritional supplement across a wide range of food products. It is FDA-approved as a GRAS ingredient for use as a nutrient supplement (source of calcium or phosphorus) in food products such as gelatins, puddings, and fillings.
Common food applications:
Bread, flour, and noodles — calcium enrichment of staple foods
Soy milk and plant-based beverages — fortification to match dairy calcium levels
Infant formula — CaGP is an FDA-approved calcium source for infant formulas, providing essential minerals for bone development during infancy
Functional foods and beverages — calcium-fortified drinks, energy bars, and nutritional powders
Baking powder — acts as both a nutrient supplement and a food stabilizer
Usage levels: Typically below 1% in food products.
4. Parenteral Nutrition — Intravenous Mineral Source
In clinical settings, CaGP serves as a source of calcium and phosphorus in total parenteral nutrition (TPN) solutions. Research has demonstrated that CaGP provides substantially higher calcium and phosphorus retention compared to traditional sources like calcium gluconate and potassium phosphate combinations.
Key clinical evidence:
In animal studies, piglets receiving CaGP retained more than six times greater amounts of both calcium and phosphorus compared to those receiving calcium gluconate + potassium phosphate (14.5 ± 0.2 vs. 2.2 ± 0.3 mmol Ca/kg/24 h)
Bone mineralization indicators were significantly higher in the CaGP group
Particularly beneficial for preventing under-mineralized bone development in low-birth-weight infants receiving intravenous nutrition
5. Gastrointestinal Health — Acid Neutralization & Symptom Relief
CaGP acts as an effective buffering agent that neutralizes stomach acid, providing relief from acid-related conditions. This is the basis for its use in the Prelief product line.
Approved palliative uses:
Interstitial cystitis — reduces dietary acid triggers that exacerbate bladder inflammation
Prostatitis — palliative management of acid-related symptom flares
Overactive bladder — symptom reduction through acid neutralization
Irritable bowel syndrome (IBS) — symptom reduction through gastrointestinal buffering
Heartburn and acid reflux — direct neutralization of excess gastric acid
6. Cell Biology & Tissue Engineering Research
In laboratory research, CaGP is widely used as a component of mineralization media to promote osteoblast differentiation and study bone formation mechanisms.
Research applications:
Osteoblast differentiation — β-glycerophosphate serves as a phosphate donor in mineralization (culture media), facilitating calcium phosphate crystal deposition in the bone matrix
Bone tissue engineering — used as a precursor for controlled release of calcium and phosphate ions in biocompatible cement formulations
In vitro biomineralization studies — aids in examining osteoblast activity and calcium phosphate deposition mechanisms
7. Cosmetics & Personal Care
CaGP is increasingly used in the cosmetics industry as a skin-protecting and moisturizing agent. It is listed in China's Inventory of Used Cosmetic Ingredients (2021 Edition) (Item No. 02456) and is recognized for its multifunctional properties in skincare formulations.
Cosmetic functions:
Skin hydration — enhances moisture retention in skin formulations
Skin barrier repair — aids in restoring the skin's protective barrier function
Anti-aging formulations — incorporated into serums and creams for its mineral-nourishing properties
Clean beauty trend — valued as a natural, safe, and biocompatible ingredient
8. Pharmaceutical Excipient
CaGP is being explored as a functional excipient in drug formulation due to its biocompatibility and ability to enhance the solubility and stability of active pharmaceutical ingredients (APIs). Its incorporation could lead to improved bioavailability of certain medications.
Key Selling Points
| Selling Point | Explanation |
|---|---|
| Dual-mineral delivery | Uniquely provides both highly bioavailable calcium AND phosphorus in a single organic compound — no other common calcium salt offers this |
| Superior bioavailability | Organic glycerophosphate structure ensures significantly higher intestinal absorption compared to inorganic calcium salts (carbonate, phosphate) |
| GRAS status (FDA) | Recognized as Generally Recognized As Safe, enabling broad use in foods, supplements, infant formula, and oral care products without regulatory barriers |
| Multi-industry versatility | A single compound serving pharmaceuticals (64% market share), food & beverage, oral care, cosmetics, and research — reducing supply chain complexity |
| Proven anti-caries efficacy | Decades of clinical evidence demonstrating enamel remineralization, plaque buffering, and synergistic effects with fluoride in dental products |
| Gentle GI profile | Alkaline-buffering action neutralizes stomach acid without the constipation, bloating, or gas commonly associated with calcium carbonate supplements |
| Infant formula approved | One of the few calcium sources FDA-approved for use in infant formulas, addressing critical bone development needs in early life |
| Parenteral nutrition superiority | Delivers 6× greater calcium/phosphorus retention vs. traditional IV mineral sources — critical for neonatal and critical care nutrition |
| Growing market trajectory | Global market valued at USD 75.41 million (2025), projected to reach USD 110.56 million by 2035 (3.9% CAGR), with Asia-Pacific as the fastest-growing region |
| Clean-label compatible | Aligns with consumer trends toward natural, safe, and recognizable ingredients in food, supplements, and personal care products |
| High-purity grades available | Pharmaceutical-grade (≥99% purity) and food-grade options available, meeting EP, NF, and FCC pharmacopeial standards |
Market Landscape
The global Calcium Glycerophosphate market is growing steadily, driven by:
Rising prevalence of osteoporosis and calcium deficiency worldwide
Growing consumer awareness of bone health and preventive nutrition
Expansion of the functional food and beverage sector
Increasing demand for premium oral care products with active remineralization ingredients
Asia-Pacific emerging as the fastest-growing regional market due to rising health consciousness and dental care awareness
Key global manufacturers include Global Calcium Pvt. Ltd., Seppic SA, Sri Vyjayanthi Labs, Penta Manufacturing Company, and Anmol Chemicals Group, with Chinese manufacturers such as Zhengzhou Ruipu Biological and Zhejiang Tianrui Pharmaceutical expanding their international presence.
Summary
Calcium Glycerophosphate is a uniquely versatile organic mineral compound whose dual calcium-phosphorus delivery, superior bioavailability, and GRAS safety profile make it indispensable across pharmaceuticals, nutrition, oral care, food fortification, clinical nutrition, and cosmetics. Its most impactful applications — serving as a premium calcium supplement for bone health and a proven anti-caries agent in dental products — underpin a growing global market. Unlike conventional inorganic calcium salts, CaGP's organic structure ensures better absorption, gentler gastrointestinal tolerance, and broader formulation compatibility, positioning it as a high-value, multi-purpose ingredient with expanding applications in health and wellness industries worldwide.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Calcium Glycerophosphate with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Calcium Glycerophosphate.
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