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2-Naphthaldehyde is an organic intermediate that is widely used in a variety of industrial fields such as pharmaceuticals, fuels, fragrances, agrochemicals and materials. 2-Naphthaldehyde can be used as a reactant: 1. In proline catalyzed aldol reaction. 2. In asymmetric three-component Mannich reaction. 3. For the synthesis of Hantzsch 1,4-dihydropyridines.13 4. Asymmetric benzoin condensation reaction. 5. For the synthesis of pyrazolo[1,2?b]phthalazinediones. 6. For the synthesis C60 by flash vacuum pyrolysis.
Items | Specification | Result |
| Assay | ≥98.0% | 98.53% |
| Appearance | Off-white to white crystalline powder | Conform |
| Melting point | 57-59℃ | Conform |
| Loss on drying | ＜0.5% | 0.38% |
| Product parameters | |
| Cas number: | 66-99-9 |
| Appearance: | Off-white to white crystalline powder |
| Purity: | 98%min |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Uses:
2-Naphthaldehyde (CAS: 66-99-9), also known as β-Naphthaldehyde or naphthalene-2-carbaldehyde, is an aromatic aldehyde with the molecular formula C₁₁H₈O and a molecular weight of 156.18. It appears as a white to light yellow crystalline powder or chunks, with a melting point of 58–61°C and a boiling point of 299.5°C (at 760 mmHg). It is soluble in organic solvents such as ethanol, ether, acetone, chloroform, and methanol, and slightly soluble in hot water.
Structurally, it consists of a naphthalene ring system with a formyl (–CHO) group at the 2-position (beta position), making it a versatile electrophilic building block in organic synthesis.
Primary Uses
1. Organic Synthesis & Named Reactions
2-Naphthaldehyde is a highly reactive aromatic aldehyde that participates in a wide range of classic organic reactions:
Proline-catalyzed asymmetric aldol reactions — enabling stereoselective carbon–carbon bond formation
Asymmetric three-component Mannich reactions — for constructing β-amino carbonyl scaffolds
Hantzsch synthesis of 1,4-dihydropyridines — important pharmacophores in calcium channel blockers
Asymmetric benzoin condensation — generating α-hydroxy ketones with controlled stereochemistry
Synthesis of pyrazolo[1,2-b]phthalazinediones — heterocyclic compounds with biological activity
Stereoselective formation of bicyclo[2.1.0] siloxy-2-alkoxyoxetanes — strained ring systems for advanced synthesis
2. Pharmaceutical Intermediate
2-Naphthaldehyde is a critical building block in drug discovery and development:
Antileishmanial agents — used to prepare chalcone analogs with enhanced activity against leishmaniasis, a serious parasitic disease
HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) — serves as a precursor for (aryl)(oxo)spiro[cyclopropane-1,3'-indole] derivatives with antiretroviral potential
Functionalized ketone derivatives — participates in chemical reactions to generate diverse pharmacologically active molecules
3. Agrochemical Intermediate
It serves as a key intermediate in the synthesis of high-performance agrochemicals, including pesticides and crop protection agents.
4. Liquid Crystal & Materials Science
2-Naphthaldehyde is used as an intermediate in the production of liquid crystal materials, contributing to display technologies and advanced functional materials.
5. Dyes, Fragrances & Petrochemical Additives
It is employed in the synthesis of dyes and fragrance compounds, and also functions as a catalytic agent and petrochemical additive.
6. Fullerene (C₆₀) Synthesis
2-Naphthaldehyde has been used in the rational chemical synthesis of C₆₀ (Buckminsterfullerene) via flash vacuum pyrolysis, demonstrating its utility in cutting-edge nanomaterial research.
Key Selling Points
High Synthetic Versatility
The aldehyde functional group at the β-position of the naphthalene ring makes 2-Naphthaldehyde an exceptionally versatile electrophile. It participates in condensation, cyclization, and functional group transformation reactions, serving as a gateway to a vast library of complex molecules across pharmaceuticals, agrochemicals, and materials science.
High Purity Availability
Commercially available in purities ranging from ≥98% (GC) up to 99.8%, ensuring reliable performance in sensitive research and industrial applications. Multiple grades are available to match specific use requirements.
Well-Defined Physical Properties
With a sharp melting point (58–61°C), good thermal stability, and predictable solubility profiles, 2-Naphthaldehyde integrates smoothly into standard laboratory and industrial workflows. Its air sensitivity is manageable with proper inert-gas storage.
Broad Multi-Industry Demand
Demand is driven by the expanding pharmaceutical sector, increasing need for high-performance agrochemicals, and continuous innovation in organic synthesis. The global market is expected to grow steadily through 2028, supported by R&D investment across drug discovery and materials science.
Established Global Supply Chain
Multiple reputable manufacturers and suppliers worldwide — including major players in China (e.g., Changzhou Anscoep Chemical), Europe (TCI), and global distributors (Sigma-Aldrich, MedChemExpress) — ensure consistent availability in quantities from grams to metric tons.
Cost-Effective at Scale
Pricing is competitive, with bulk quantities (100 g–500 g) available at significantly reduced per-gram costs, making it accessible for both academic research laboratories and industrial-scale manufacturing.
Extensive Literature & Reference Data
2-Naphthaldehyde is extensively documented in major chemical databases (NIST, PubChem, Beilstein/REAXYS, ChemicalBook) with comprehensive spectral, toxicological, and safety data, facilitating regulatory compliance and research reproducibility.
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FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide 2-Naphthaldehyde with good quality and best price, welcome to contact us to get COA/TDS/MSDS of 2-Naphthaldehyde.
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