Praziquantel has a significant effect of killing adult schistosomiasis. Its insecticidal mechanism, at the molecular level, is that praziquantel rapidly destroys the Ca2+ balance in the worm, on the one hand, it leads to the excitation of the worm's body and muscle contracture, so that the schistosomiasis parasitic in the portal system cannot be adsorbed on the blood vessel wall and brought into the liver by blood flow (liver migration), and then damaged; In addition to affecting the absorption, excretion and secretion functions of the worm, resulting in disorders of glucose metabolism and enzyme system, the body surface antigen determinant cluster of the worm is exposed, and the host's immune system is recognized, attracting a large number of inflammatory cells such as neutrophils, eosinophils, macrophages and other aggregates around the attack.
Praziquantel is used as an anti-helminth mainly for schistosomiasis.
|Appearance||The white or almost white crystalline powder||White powder|
|Loss on drying（%）||≤0.5||0.1|
|Residual on ignition（%）||≤0.1||0.04|
|Appearance:||White crystalline powder|
As broad spectrum of anti parasitic agents, used in the treatment and prevention of schistosomiasis, cysticercosis, paragonimiasis, echinococcosis, Fasciolopsiasis, hydatid disease, helminth infection etc.
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