Name: Manufacturer Supply High Quality Bulk Price 1-Chloro-4-iodobenzene CAS 637-87-6 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of 1-Chloro-4-iodobenzene CAS 637-87-6

Items	Specifications	Results
Appearance	Light brown crystal	Conforms
Assay	≥99%	99.47%

Parameters of 1-Chloro-4-iodobenzene CAS 637-87-6

Product parameters
Cas number:	637-87-6
Appearance:	Light brown crystal
Purity:	99%min
Package details:	1kg/foil bag; 25kg/drum
Brand:	Fortunachem

1-Chloro-4-iodobenzene (CAS No. 637-87-6), also known as p-chloroiodobenzene, is a di-halogenated aromatic compound featuring both a chlorine and an iodine atom at para positions on a benzene ring.

Chemical Nature: A white to off-white crystalline solid. The presence of two different halogens creates distinct reactivity profiles: the carbon-iodine bond is highly reactive towards oxidative addition, while the carbon-chlorine bond remains relatively inert under mild conditions.

Primary Applications:

Cross-Coupling Reactions: It is a premier building block for Pd-catalyzed coupling reactions (Suzuki-Miyaura, Heck, Sonogashira). Chemists selectively react the iodine site first to build complex biaryl structures, leaving the chlorine intact for subsequent functionalization steps.

Pharmaceutical & Agrochemical Synthesis: A critical intermediate in manufacturing drugs (e.g., kinase inhibitors, NSAIDs) and crop protection agents requiring precise substitution patterns.

Material Science: Used in synthesizing conjugated polymers and organic electronic materials (OLEDs, OPVs) where controlled halogen placement dictates electronic properties.

Key Selling Points

Targeted at process chemists, CROs/CDMOs, and R&D laboratories:

Selective Reactivity (Orthogonal Functionality):

Offers perfect chemoselectivity: The iodine allows for rapid, low-temperature coupling, while the chlorine serves as a stable "handle" for later-stage diversification. This reduces synthetic steps and improves overall yield in multi-step syntheses.

High Purity & Low Metal Content:

Supplied with purity >99% (GC/HPLC) and ultra-low levels of residual metals (Pd, Cu, Fe). Critical for preventing catalyst poisoning in sensitive downstream reactions and meeting strict pharmaceutical impurity limits.

Scalable & Cost-Effective:

Manufactured via efficient direct iodination or halogen exchange processes, offering a cost advantage over more complex asymmetric precursors. Available from gram-scale research quantities to metric-ton commercial supply.

Versatile Building Block:

Enables the rapid construction of diverse chemical libraries for drug discovery. Its stability ensures long shelf-life and ease of handling compared to more reactive aryl triflates or nonaflates.

Regulatory Support:

Comprehensive documentation including CoA, MSDS, and DMF support available for GMP-grade batches, facilitating smooth regulatory filings for active pharmaceutical ingredients (APIs).

Important Notice: This product is sold strictly as a chemical intermediate for laboratory research and industrial manufacturing. It is not for direct human consumption or use as a finished drug product.