Name: Chemical Manufacturer Top Purity Best Price 1-Adamantanecarboxylic Acid CAS 828-51-3
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of 1-Adamantanecarboxylic Acid CAS 828-51-3

Product Name	1-Adamantanecarboxylic acid
Apperance	White crystalline powder
EINECS	212-584-6
MF	C11H16O2
MW	180.24
Assay	≥99.0%

Parameters of 1-Adamantanecarboxylic Acid CAS 828-51-3

Product parameters
Cas number:	828-51-3
Appearance:	White crystalline powder
Purity:	99.0%min
Package details:	25kg/bag;25kg/drum or as you require
Brand:	Fortunachem

1-Adamantanecarboxylic acid (also known as 1-Adamantane carboxylic acid or Adamantane-1-carboxylic acid) is an organic compound with the chemical formula C₁₁H₁₆O₂ and a molecular weight of approximately 180.25 g/mol. It consists of an adamantane cage structure (a rigid, tricyclic hydrocarbon) substituted with a carboxylic acid group at the 1-position.

Key Characteristics & Properties:

Structure: It features the highly stable and lipophilic adamantane skeleton, which is known for its unique three-dimensional rigidity.

Physical State: Typically appears as a white to off-white crystalline powder.

Solubility: Generally insoluble in water but soluble in organic solvents like ethanol, ether, and chloroform.

CAS Number: 828-51-3.

Primary Applications:

Its main value lies in its role as a chemical intermediate, particularly in the pharmaceutical industry:

Pharmaceutical Synthesis: It is a crucial building block for synthesizing various adamantane-derived drugs. The adamantane moiety is often incorporated into drug molecules to improve their lipophilicity, metabolic stability, and ability to cross the blood-brain barrier.

It is structurally related to compounds like Memantine (used for Alzheimer's disease) and Amantadine (an antiviral and antiparkinsonian agent), although these specific drugs are often synthesized via different direct routes, 1-adamantanecarboxylic acid serves as a key precursor for many analogs and derivatives in this class.

It is used to create amides and esters that serve as active pharmaceutical ingredients (APIs) or prodrugs.

Material Science: Due to the rigidity of the adamantane cage, derivatives are sometimes used in the development of polymers and advanced materials to enhance thermal stability and mechanical properties.

Research: Used in organic synthesis research as a model compound for studying steric effects and reaction mechanisms involving bulky groups.

Selling Points (Why it is valuable):

If you are looking at this from a procurement or sales perspective, the "selling points" usually revolve around its utility in high-value synthesis:

High Purity Availability: Suppliers often emphasize high purity grades (e.g., >98% or >99%) which are critical for pharmaceutical GMP manufacturing to minimize impurities in the final drug product.

Structural Rigidity & Lipophilicity: The adamantane group provides a unique "pharmacophore" that enhances the biological activity of drug candidates by improving membrane permeability and binding affinity to hydrophobic pockets in proteins.

Versatile Reactivity: The carboxylic acid group allows for easy conversion into various derivatives such as acid chlorides, esters, and amides, making it a flexible starting material for multi-step synthesis.

Metabolic Stability: Compounds derived from this acid often exhibit resistance to metabolic degradation, leading to longer half-lives in vivo, a highly desirable trait in drug design.

Niche Supply: As a specialized intermediate, reliable supply chains with proper documentation (COA, MSDS) are a significant selling point for manufacturers who cannot easily synthesize it in-house.

In summary, 1-Adamantanecarboxylic acid is not typically a consumer product but a high-value specialty chemical intermediate prized in the pharmaceutical industry for its ability to impart favorable pharmacokinetic properties to new drug candidates.