Enalapril maleate is a potent angiotensin-converting enzyme (ACE) inhibitor that is hydrolyzed in vivo to Enalaprilat, which exerts ACE inhibition effect. Its mechanism of action is the conversion of angiotensin I into angiotensin II., then the vascular smooth muscle tone is weakened, aldosterone secretion is reduced, and blood pressure is reduced. Its antihypertensive effect is 10 times stronger than captopril and is more durable. Its antihypertensive effect is slow and long-lasting. Its hemodynamic effect is similar to captopril, which can reduce total peripheral vascular resistance and renal vascular resistance, and increase renal blood flow. Long-term application can reverse left ventricular hypertrophy and improve ventricular remodeling.
Enalapril maleate is used to treat hypertension, diabetic nephropathy, and chronic heart failure.
|Appearance||A white or almost white crystalline powder||White crystalline powder|
|Melting range||About 144℃||143.5℃～144.5℃|
|Loss on drying||≤1.0%||0.1%|
|Residue on ignition||≤0.2%||0.1%|
Any other impurity
|Appearance:||White crystalline powder|
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