Name: China Chemical Factory Supply High Quality Sodium Butazolidine CAS 129-18-0 with best price
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Sodium Butazolidine CAS 129-18-0

Item	Specifications	Results
Appearance	White or almost white crystalline powder	Conform
Heavy Metal	≤20ppm	< 10ppm
PH	8.0 – 9.5	9.2
Water	5.0 – 14.0%	6.7%
Assay	99.0 – 101.0% on dry base(Ticration) 95.0 – 99.0% on dry base(HPLC)	99.9%

Parameters of Sodium Butazolidine CAS 129-18-0

Product parameters
Cas number:	129-18-0
Appearance:	White or almost white crystalline powder
Purity:	99.0 – 101.0% on dry base(Ticration) 95.0 – 99.0% on dry base(HPLC)
Package details:	25kg/drum
Brand:	Fortunachem

Phenylbutazone sodium is the sodium salt form of phenylbutazone. In its pure, chemical grade form, it is a fine, yellowish-white to white crystalline powder. It is highly soluble in water, unlike the parent compound phenylbutazone, which is poorly soluble.

Chemical Name: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione monosodium salt
CAS Number: 129-18-0
Key Property: Its high water solubility makes it preferable for in vitro experimental applications where consistent dissolution is critical.

Pharmaceutical vs. Chemical Grade

It's crucial to distinguish between its historical medical use and its current chemical application:

Pharmaceutical Use (Largely Obsolete): Phenylbutazone was once a widely used non-steroidal anti-inflammatory drug (NSAID) for humans (brand name: Butazolidin) and later primarily for horses (as a "bute"). Due to severe potential side effects in humans (like bone marrow suppression), its human use has been banned or severely restricted in most countries (including the USA and EU). Its veterinary use is now also heavily controlled.
Chemical / Research Grade: This refers to the compound sold by chemical suppliers (e.g., Sigma-Aldrich, TCI) with a high degree of purity (e.g., ≥98%, 99%), intended solely for laboratory research purposes. It is not for human or veterinary therapeutic use.

Uses in Chemical and Research Grade

In a research context, phenylbutazone sodium serves as a chemical tool or reference standard. Its primary uses include:

Pharmacological and Biochemical Research:

Model NSAID: It is used as a classic, non-selective cyclooxygenase (COX) inhibitor in studies investigating the mechanism of action of NSAIDs, inflammation pathways, and prostaglandin biology.
Enzyme Inhibition Studies: Researchers use it to study the kinetics and structural aspects of COX-1 and COX-2 enzyme inhibition.

Analytical Chemistry:

Identify and quantify phenylbutazone residues.
Validate analytical methods for detecting phenylbutazone in biological samples, environmental samples, or feed (important for food safety testing in racing and livestock industries).

Reference Standard: It is used as a high-purity standard in analytical methods like High-Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS), or thin-layer chromatography (TLC) to:

Veterinary and Food Safety Research:

Method Development: Labs use chemical-grade phenylbutazone sodium to develop and test sensitive assays for detecting illegal or off-label use in food-producing animals, ensuring compliance with bans (e.g., in dairy cattle or animals destined for human consumption).

Metabolic and Toxicological Studies:

Researchers study its metabolic pathways, degradation products, and toxicological effects in vitro (in cell cultures) or in controlled animal models to understand its pharmacology and side-effect profile better.

Key Points for Chemical Handling

Not for Human or Animal Use: Strictly for laboratory analysis.
Hazardous: It is classified as harmful if swallowed, causes skin and eye irritation, and may cause organ damage with prolonged exposure. Safety data sheets (SDS) must be consulted.
Regulatory Status: While available for research, it is often a controlled substance due to its potential for misuse in sports (e.g., horse racing). Researchers must comply with local regulations regarding purchase, storage, and record-keeping.

Summary

Aspect	Description
Identity	Sodium salt of phenylbutazone, a pyrazolone derivative.
Chemical Grade	High-purity form sold for non-therapeutic laboratory use.
Primary Research Uses	1. Biochemical Tool: Non-selective COX inhibitor in inflammation studies. 2. Analytical Standard: For calibrating equipment and testing for residues. 3. Toxicology & Metabolism: Studying its effects and breakdown.
Key Distinction	It is a research chemical, not a medication for use in humans or animals.

In essence, chemical-grade phenylbutazone sodium is a valuable reference compound and research tool for scientists studying anti-inflammatory drugs, developing detection methods, and investigating biochemical pathways, long after its therapeutic use has been phased out.