Name: China Manufacturer Supply High Quality Prednisone CAS 53-03-2 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications Of Prednisone CAS 53-03-2

Items	Specifications	Results
Appearance	White to practically white,crystalline powder	White crystalline Powder
Identification	A:IR B:Chemistry reaction	Complies Complies
Melting Point	About 230℃,with some decomposition	Complies
Specific Optic rotation	+167°~ +175°	+170°
Residue on ignition	Negligible	Negligible
Water	≤1.0%	0.1%
Assay	97%-102%(on anhydrous basis)	98.3%
Related Substances	Any individual impurity≤1.5%	0.33%
Related Substances	Total impurity≤2.0%	1.2%
Residual Solvents	Methanol≤3000 ppm	Complies
	Acetone≤5000 ppm	Complies
	Dichloroform≤600 ppm	Complies
Conclusion	The product conforms to the above specifications.

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Parameters Of Prednisone CAS 53-03-2

Product parameters
Cas number:	53-03-2
Appearance:	White crystalline powder
Purity:	97%-102%
Package details:	1kg/foil bag
Brand:	Fortunachem

Prednisone is a potent, synthetic glucocorticoid, which is a man-made version of the cortisol hormone naturally produced by your adrenal glands. It belongs to the class of medications known as corticosteroids (or just "steroids," not to be confused with anabolic steroids used for muscle building).

It is one of the most commonly prescribed oral corticosteroids in the world due to its effectiveness and versatility.

Key Distinction: Prednisone vs. Prednisolone

This is a crucial point, especially following the previous discussion:

Prednisone is a "prodrug." It is inactive when you take it.
Your liver must metabolize (convert) it into prednisolone, which is the active anti-inflammatory drug.
This is why prednisone is almost always administered orally (as a tablet or liquid) and is not used for eye drops or direct injections—it requires liver activation.
People with severe liver disease may be prescribed prednisolone directly (the active form) to ensure effectiveness.

Key Uses (Medical Indications)

Prednisone is a "disease-modifying" drug used for its powerful anti-inflammatory, anti-allergic, and immunosuppressive effects. Doctors prescribe it for a wide range of conditions, typically to quickly control severe inflammation or an overactive immune system.

1. Allergic and Inflammatory Conditions

Severe allergies and asthma: For acute asthma attacks not controlled by inhalers, or severe allergic reactions (angioedema, contact dermatitis).
Chronic Obstructive Pulmonary Disease (COPD): To manage acute flare-ups.

2. Autoimmune Diseases

This is one of its primary uses. It suppresses the immune system when it mistakenly attacks the body's own tissues.

Rheumatoid Arthritis
Systemic Lupus Erythematosus (SLE)
Inflammatory Bowel Disease (IBD): Crohn's disease and Ulcerative colitis flares.
Multiple Sclerosis: To manage acute relapses.
Vasculitis (e.g., Giant Cell Arteritis, Polymyalgia Rheumatica)

3. Skin Diseases

Severe psoriasis
Pemphigus vulgaris
Severe eczema that doesn't respond to topical treatments.

4. Organ Transplantation

Used as part of an immunosuppressant regimen to prevent the body from rejecting a transplanted organ (like a kidney or heart).

5. Certain Cancers

Used in chemotherapy protocols for cancers like leukemia and lymphoma because it can kill certain cancer cells (lymphocytes).

6. Endocrine Disorders

To replace cortisol in conditions like Adrenal Insufficiency (Addison's disease) or Congenital Adrenal Hyperplasia.

How It Works (Mechanism of Action)

Once converted to prednisolone in the liver, it works similarly to the drug described previously:

It enters cells and binds to glucocorticoid receptors.
It turns down the genes responsible for producing inflammatory proteins (cytokines, prostaglandins).
It turns up the genes that make anti-inflammatory proteins.
It suppresses the activity of white blood cells (immune cells), reducing the immune response.

Critical Considerations: Dosing, Side Effects, and "Tapering"

Dosing Philosophy:

"Lowest effective dose for the shortest possible time." This mantra guides its use to minimize side effects.
Dosing varies wildly: from 5-10 mg daily for mild arthritis, to 60-100+ mg daily for an acute autoimmune flare or organ transplant.

Common and Serious Side Effects:
Side effects depend heavily on the dose and duration of treatment.

Short-term use (a few days to weeks): Increased appetite, insomnia, mood swings (euphoria or irritability), fluid retention, elevated blood sugar.
Long-term use (months to years):

Adrenal Suppression: The body's own cortisol production shuts down. This is why you cannot stop prednisone suddenly.
Cushing's syndrome: Moon face, weight gain (central obesity), buffalo hump.
Metabolic: High blood pressure, diabetes, high cholesterol.
Musculoskeletal: Osteoporosis, muscle weakness, avascular necrosis (bone death).
Others: Increased infection risk, thin skin/easy bruising, cataracts, glaucoma, peptic ulcers.

The Imperative of "Tapering":
This is the most important safety rule with prednisone. If taken for more than 1-2 weeks, the dose must be gradually reduced ("tapered") under a doctor's supervision.

Reason: To allow your dormant adrenal glands time to "wake up" and start producing cortisol again.
Risk of Sudden Stopping: Adrenal crisis—a life-threatening condition involving severe fatigue, low blood pressure, shock, and death.

Comparison at a Glance: Prednisone vs. Prednisolone Sodium Phosphate

Feature	Prednisone	Prednisolone Sodium Phosphate
Form	Oral tablets/liquid (primarily)	Eye drops, injectables, oral solution
State in Body	Inactive Prodrug	Water-soluble salt of the active drug
Activation	Must be converted to prednisolone by the liver	Quickly converted to prednisolone in tissues/blood
Onset	Slower (requires liver processing)	Rapid (already in soluble, active-ready form)
Primary Use	Systemic treatment of chronic inflammation, autoimmune diseases	Local treatment (eyes, ears) & urgent systemic needs (IV/IM injection)

Summary

Prednisone is an oral, prodrug corticosteroid that is a cornerstone treatment for managing severe inflammatory and autoimmune conditions. Its strength lies in its ability to rapidly and powerfully suppress the immune system. However, this power comes with a significant risk of side effects, especially with long-term use, making medical supervision, careful dosing, and mandatory dose tapering absolutely essential.

Disclaimer: This information is for educational purposes only. Prednisone is a prescription medication with serious risks. Always follow your doctor's instructions regarding its use, dosing, and discontinuation.