Bortezomib is a drug for the treatment of malignant tumors of the hematopoietic system. Bortezomib is the first proteasome inhibitor to be used clinically. Proteasomes are present in all eukaryotic cells and degrade more than 80% of proteins within cells. It reversibly inhibits the function of the proteasome, thereby inhibiting the degradation of proteins, leading to protein accumulation and apoptosis. Because multiple myeloma (MM) continuously replicates and secretes myeloma proteins, it is more sensitive to proteasomes than normal cells and can be used as a second-line treatment for MM and mantle cell lymphoma.
White or off-white powder
Loss on drying
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|Appearance:||White or off-white powder|
|Package details:||1kg/bag with foil bag;1kg/bottle|
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