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Alendronate sodium is an amino bisphosphonate bone resorption inhibitor, and intraosseous hydroxyapatite has a strong affinity, can enter the bone matrix hydroxyapatite crystals, when osteoclasts lyse crystals, the drug is released, can inhibit osteoclast activity, and indirectly inhibit bone resorption through osteoblasts, with strong anti-bone resorption activity, no bone mineralization inhibition characteristics. Alendronate sodium is used to treat postmenopausal osteoporosis and senile osteoporosis, osteoporosis, ectopic ossification, such as Paget's disease, deforming osteitis, kidney stones, malignant hypercalcemia, etc.
Alendronate sodium is the most widely used anti-osteoporosis drug in the world. It can significantly increase the bone density of patients, reduce the risk of fractures, and is a first-line treatment for osteoporosis.
| Items | Specifications | Results |
| Appearance | The white or off-white crystalline powder | White crystalline powder |
| Phosphate and phosphite | ≤0.5% | 0.27% |
| Loss on drying | 16.1-17.1% | 16.9% |
| Heavy metal | ≤10 ppm | Conforms |
| Assay | 98.0-102.0% | 99.83% |
| Product parameters | |
| Cas number: | 121268-17-5 |
| Appearance: | White crystalline powder |
| Purity: | 98.0-102.0% |
| Package details: | 1kg/ foil bag; 25kg/drum |
| Brand: | Fortunachem |
Product Name:Alendronate Sodium
CAS:121268-17-5
MF:C4H13NO7P2.3H2O.Na
Melting point :245°C
form:powder
color:White
Uses:
Alendronate Sodium Trihydrate is a third-generation bisphosphonate medication used to treat osteoporosis. Its core function is to inhibit bone loss, increase bone mineral density, and reduce the risk of fractures. It is a first-line oral medication for treating postmenopausal and male osteoporosis.
Mechanism of Action
Alendronate sodium trihydrate has a strong affinity for hydroxyapatite crystals in the bone matrix. When osteoclasts (bone-resorbing cells) dissolve bone, the drug is released and directly inhibits osteoclast activity, thereby reducing bone resorption. It has a potent anti-resorptive effect without inhibiting bone mineralization, meaning it does not interfere with normal bone formation.
Primary Indications
Clinically, it is mainly used to treat osteoporosis in postmenopausal women, increasing bone mass and preventing hip and spinal (vertebral compression) fractures. Additionally, it is used to treat osteoporosis in men, as well as glucocorticoid-induced osteoporosis.
Key Features & Selling Points
Proven Efficacy: As one of the most widely used anti-osteoporosis drugs globally, it is a primary bisphosphonate that significantly improves bone microarchitecture.
Convenient Dosing: Available in daily (10 mg) and weekly (70 mg) tablet formulations. The once-weekly dosing greatly enhances long-term patient compliance.
Favorable Safety Profile: Most patients tolerate the drug well, and adverse effects are typically mild and usually do not require discontinuation of treatment.
Crucial Administration Guidelines
Strictly Fasting: It must be taken first thing in the morning, at least 30 minutes before your first food, beverage, or other medication, with a full glass of plain water (approx. 200 ml).
Remain Upright: Do not lie down immediately after taking the pill. You must remain completely upright (standing or sitting straight) for at least 30 minutes to allow gravity to help the medication pass quickly through the esophagus into the stomach.
Avoid Concurrent Medications: Calcium supplements, antacids, and other oral medications can interfere with the absorption of alendronate. You must wait at least 30 minutes after taking this medication before taking anything else.
Key Safety Warnings
This drug can cause local irritation to the upper gastrointestinal mucosa. It is generally contraindicated or requires extreme caution in patients with swallowing difficulties, esophageal disorders, severe gastrointestinal diseases, or severe renal impairment. If you experience new or worsening heartburn, pain upon swallowing, or retrosternal pain (pain behind the breastbone), stop the medication immediately and consult a doctor.
Summary
In short, Alendronate Sodium Trihydrate is a "workhorse" in anti-osteoporosis therapy. However, to safely and effectively protect bone health, patients must strictly adhere to the administration rules ("fasting, plenty of water, remain upright after dosing") and ensure adequate supplementation of calcium and vitamin D.
Also, if you have any other questions, you can contact us
FAQ From Wuhan Fortuna Chemical Co.,Ltd
Q1: Can I get a sample for free ?
A: For small QTY and low value product, we can provide sample for free exclude shipping cost. For high value sample, we will charge the basic sample cost, but we can refund all the cost if customers place order after sample test.
Q2: How to confirm the product quality before placing orders ?
A: Most of our products confirm to international standards like USP/EP/BP/JP/CP. We will provide COA/TDS/MSDS for customers to confirm the specification before placing order.
Q3: What is the payment you accept?
A: For small and low value order, we accept CreditCard, MaterCard,VISA,Western Union and T/T.For large order, we can do T/T and L/C. Any pay on delivery or pay-after are not available for us.
Q4: What is your shipment way ?
A: For less than 100kg gross weight order will ship with courier like FedEx or UPS, we support customers to place courier orders remotely by their account, we will package the goods well and wait for pick up.For more than 100kg goods, we will transport by Air or Sea according to customers' requirement.
Q5: How long is your after-sales service?
A: We accept customer’s quality complaint in three month after customer received the goods. We provide tech.support for all-life if customer place order from our company.
Q6: How do you treat quality complaint ?
A: We support customer to provide our products to any rightful third party testing organization to test our products according to the COA specification, if the test result is confirm with COA, we will take all the loss for customers.
Name:Wuhan Fortuna Chemical Co.,Ltd
Category:Others
Trade Category: Trading Company
Employees: 11 - 50 People
Address: Room 2015, No.2 Building, Kaixin Mansion No.107
Company Information: Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical and Intermediates, Food and Feed additives, Fine chemicals,Biochemical and Reagent, which is the members of Hubei E-commerce Chamber.
Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement.
We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves.
Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward power, their satisfaction is our struggling goal.
Wuhan Fortuna Chemical Co.,Ltd is a professional manufacturer which provide Azaperone with good quality and best price, welcome to contact us to get COA/TDS/MSDS of Azaperone.
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