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2-Aminobenzylalcohol is used as a pharmaceutical intermediate.
2-Aminobenzyl alcohol is an aromatic compound containing both an amino (–NH₂) and a hydroxymethyl (–CH₂OH) group attached to adjacent positions on a benzene ring. This ortho relationship makes it a versatile bifunctional building block in synthesis.
Its primary use is as a key intermediate in pharmaceutical and agrochemical research, especially for constructing important heterocycles like benzoxazoles and quinazolines, which are cores of many active molecules. It also serves as a chelating ligand in metal coordination chemistry and as a monomer in synthesizing specialty polymers, such as polybenzoxazines. Additionally, it finds application in dye manufacturing.
In essence, this compound's value lies in its two adjacent functional groups, enabling the efficient synthesis of complex, useful structures in medicinal and materials chemistry.
Items | Specifications | Results |
Appearance | White to off-white or light brown solid | Off-white solid |
Water | ≤0.5% | 0.07% |
Purity（GC） | ≥99.0% | 99.97% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 5344-90-1 |
| Appearance: | Yellow crystalline powder |
| Purity: | 99%min |
| Package details: | 25kg/drum or per your request |
| Brand: | Fortunachem |
2-Aminobenzyl alcohol is an organic compound with the formula C₆H₄(CH₂OH)(NH₂), featuring both an amino (–NH₂) and a hydroxyl (–CH₂OH) group attached to a benzene ring in ortho positions. It is typically a white to off-white crystalline solid.
It is a versatile bifunctional building block in organic synthesis. The proximity and differing reactivity of the amine and alcohol groups make it a valuable intermediate for constructing complex molecules.
Pharmaceutical & Agrochemical Intermediates
It is a key precursor in synthesizing a range of heterocyclic compounds, most importantly benzoxazoles and quinazolines.
These core structures are found in molecules with biological activity, leading to its use in developing potential drugs (e.g., antimicrobials, kinase inhibitors) and agrochemicals.
Ligand in Coordination Chemistry
The molecule can act as a chelating ligand for metal ions (like Cu, Ni, Pd), using both its nitrogen and oxygen donor atoms. These metal complexes are studied for catalysis, materials science, and as models for biological systems.
Polymer and Material Science
Serves as a monomer or modifier in the synthesis of specialty polymers, such as polybenzoxazines (high-performance resins) and functionalized polyamides.
Dye and Pigment Synthesis
Used as an intermediate in the production of certain organic dyes and pigments.
It is an irritant and should be handled with appropriate personal protective equipment (PPE) in a well-ventilated laboratory setting.
In summary, 2-aminobenzyl alcohol is primarily a synthetic intermediate valued for its dual functionality, enabling the construction of pharmacologically active heterocycles, metal-chelating ligands, and specialized polymers.
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