English 
Español 
français 
العربية Search
Search
Granisetron hydrochloride is used as an antiemetic for nausea and vomiting caused by chemotherapy and radiation therapy.
Granisetron hydrochloride is a highly selective 5-HT3 receptor antagonist with good preventive and therapeutic effects on nausea and vomiting caused by radiotherapy, chemotherapy and surgery. Radiotherapy, chemotherapy, and surgery can cause intestinal chromaffin cells to release 5-HT, which activates 5-HT3 receptors in the central or vagus nerve and causes a gag reflex. The mechanism of granisetron hydrochloride to control nausea and vomiting is to inhibit the occurrence of nausea and vomiting by antagonizing the 5-HT3 receptors of the central chemoreceptor and peripheral vagus nerve endings. Granisetron hydrochloride has high selectivity and no side effects such as extrapyramidal reactions and excessive sedation.
Items | Specification | Result |
| Assay | 97.0%~102.0%(dried substance) | 99.88% |
| Appearance | White or almost white powder | Conforms |
| Loss on drying | ≤0.5% | 0.18% |
| Average particle size | 100 micon:80%;100-120Micron:20% | Conforms |
| Sulphated ash | ≤0.1% | 0.08% |
| Impurity E (TLC) | ≤0.5% | Conforms |
| Residual solvents | Methanol ≤0.3% Ethanol ≤0.5% Methylene dichloride ≤0.06% | 0.04% Not detected Not detected |
| Related substances(HPLC) | Impurity A ≤0.5% Impurity B ≤0.5% Impurity C ≤0.2% Impurity D ≤0.1% Any other impurity ≤0.1% Total Impurity ≤1.0% | 0.01% 0.01% 0.08% 0.01% Not detected 0.13% |
| Product parameters | |
| Cas number: | 107007-99-8 |
| Appearance: | White or almost white powder |
| Purity: | 97.0%~102.0% |
| Package details: | 1kg/foil bag |
| Brand: | Fortunachem |
Guaranteed purity
High quality & competitive price
Quality control
Fast feedback
Prompt shipment
Fortunachem Provides Not Only Professional Chemical Products But Also Professional Help
Keeping you up-to-date with all the latest information, news, and events about Fortunachem!
Quick Links
Add:
E-mail:
