Name: China Factory Supply High Quality Clotrimazole CAS 23593-75-1 with best service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Clotrimazole CAS 23593-75-1

Items	Specifications	Results
Appearance	White or pale yellow, crystalline powder	White crystalline powder
Melting Point(℃)	141~145℃	144~145℃
Identification	A.Infrared absorption:The IR spectrum of sample,exhibits maxima only at the same wavelength as that a similar preparation of USP Clotrimazole RS.	Complies
Identification	B.HPLC:The retention time of the major peak of the sample solution Corresponds to that of the standard solution,as obtained in the assay.	Complies
Loss on Drying	NMT 0.5%	0.1%
Residue on Ignition	NMT 0.1%	0.03%
Heavy Metals	NMT 10 ppm	Complies
Limit of Imidazole	NMT 0.5%	Complies
Limit Of Clotrimazole Related Compound A	NMT 0.5%	0.022%
Solubility	---	Freely soluble in methanol,in chloroform.Soluble in alcohol,in acetone.Practically insoluble in water.
Residual Solvent	---	Benzene:0.000075% Acetone:0.054%
Assay(on the dried basis)	98.0%~102.0%	99.1%
Conclusion	The product conforms to the above specifications.

Parameters of Clotrimazole CAS 23593-75-1

Product parameters
Cas number:	23593-75-1
Appearance:	White to pale yellow,crystalline powder
Purity:	98%-102%
Package details:	25kg/drum
Brand:	Fortunachem

Clotrimazole is a broad-spectrum antifungal medication belonging to the imidazole class. It is primarily used to treat infections caused by fungi (like yeast and dermatophytes) and some gram-positive bacteria.

How It Works (Mechanism of Action)

Clotrimazole works by damaging the cell membrane of fungal cells.

It inhibits the synthesis of ergosterol, a critical component of the fungal cell membrane.
Without proper ergosterol, the membrane becomes leaky and permeable, causing essential cellular components to leak out. This ultimately kills the fungus or inhibits its growth.

Primary Uses and Applications

Clotrimazole is available in various formulations for topical (on the skin/mucous membranes) and, less commonly, oral use.

1. Topical Uses (Most Common)

Used for superficial fungal infections of the skin, nails, and mucous membranes.

Cutaneous Candidiasis: Fungal skin infections like diaper rash, intertrigo (rash in skin folds), and infections around nails (paronychia).
Dermatophyte Infections: Treats tinea infections such as:

Athlete's foot (Tinea pedis)
Jock itch (Tinea cruris)
Ringworm (Tinea corporis)

Vaginal Yeast Infections: Available as vaginal creams, tablets, or suppositories for treating vulvovaginal candidiasis.
Oral Thrush: Available as a troche (lozenge) that is slowly dissolved in the mouth to treat Candida infections in the mouth and throat.

2. Other Uses

Otic Drops: Sometimes combined with an antibiotic (e.g., betamethasone/clotrimazole/gentamicin) to treat outer ear infections ("swimmer's ear") where fungus may be involved.
Limited Systemic Use: An oral tablet form exists but is rarely used systemically today due to the availability of safer, more effective oral antifungals. Its primary use remains topical.

Available Forms & Key Points

Forms: Cream (1%, 2%), Lotion, Solution, Powder, Vaginal Cream/Tablets, Oral Troches, Combination Ear/Eye Drops.
Over-the-Counter (OTC): Many clotrimazole products for skin and vaginal use are available without a prescription.
Prescription Required: Oral troches and some higher-strength or combination formulations require a prescription.

Safety, Side Effects, and Considerations

Common Side Effects (Topical): Usually mild and localized, such as:

Redness, stinging, burning, itching, or irritation at the application site.
For vaginal use: mild burning, itching, or discharge.

Serious Side Effects (Rare): Severe skin irritation or allergic reactions (hives, difficulty breathing, swelling). Discontinue use and seek medical help if these occur.
Important Considerations:

For External Use: Most formulations are not for ophthalmic (eye) use unless specifically labeled as eye drops.
Complete the Course: Use for the full recommended time, even if symptoms improve quickly, to prevent recurrence.
Diagnosis: It's best to have a fungal infection confirmed by a doctor before starting treatment, especially for the first time.
Pregnancy/Breastfeeding: Generally considered safe for topical use during pregnancy and breastfeeding, but it's advised to consult a doctor first, especially for vaginal treatments.

Summary

Clotrimazole is a widely used, effective antifungal medication available over-the-counter in many forms. Its primary uses are for treating common skin fungal infections (like athlete's foot, jock itch, ringworm), vaginal yeast infections, and oral thrush. It works by disrupting the fungal cell membrane. While generally safe with minimal side effects, it is crucial to use it as directed and consult a healthcare provider for proper diagnosis of persistent or severe infections.