Name: China Supplier High Quality Clindamycin Phosphate CAS 24729-96-2 with best price
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Clindamycin Phosphate CAS 24729-96-2

Items	Specifications	Results
Appearance	White to off-white crystalline powder	White crystalline powder
Identification	IR:Meets the requirements	Conform
Identification	HPLC:retention time conforms to RS	Conform
Crystallinity	Conform	Conform
PH	3.5~4.5	4.0
Water	≤ 6.0%	0.41%
Assay	≥758μg/mg clindamycin on the anhydrous substance	836μg/mg
Organic Impurities	Lincomycin phosphate ≤1.0%	0.049%
	Lincomycin ≤0.5%	N.D.
	Clindamycin B phosphate ≤1.5%	0.053%
	7-Epiclindamycin phosphate ≤0.8%	0.21%
	Clindamycin 3-phosphate ≤0.3%	N.D.
	Clindamycin ≤0.5%	N.D.
	Any indivdual,unspecified impurity ≤1.0%	N.D.
	Total impurities ≤4.0%	0.31%
Residual solvents	Methanol ≤3000ppm	0.3
	Ethanol ≤5000ppm	580ppm
	Acetone ≤5000ppm	N.D.
Conclusion	The product conforms to the above specifications.

Parameters of Clindamycin Phosphate CAS 24729-96-2

Product parameters
Cas number:	24729-96-2
Appearance:	White crystalline powder
Purity:	≥758ug/mg
Package details:	25kg/drum
Brand:	Fortunachem

Clindamycin Phosphate: Overview & Uses

Clindamycin phosphate is a water-soluble prodrug ester of the antibiotic clindamycin. It is inactive until converted by enzymes in the body into biologically active clindamycin.

Class: Lincosamide antibiotic.
Key Advantage: The phosphate ester form allows for parenteral administration (injection) and topical formulation, as it is much more soluble than clindamycin base.

Mechanism of Action

Once converted to active clindamycin, it works by binding to the 50S subunit of the bacterial ribosome. This inhibits bacterial protein synthesis, preventing bacteria from growing and multiplying (it is primarily bacteriostatic).

Primary Uses & Applications

1. Topical Formulations (Most Common Use):

Acne Vulgaris: A first-line topical treatment for inflammatory acne (gels, lotions, foams). Often combined with benzoyl peroxide.
Bacterial Vaginitis: Used as a vaginal cream or suppository.
Skin Infections: Topical solutions for minor bacterial skin infections.

2. Parenteral (Injectable) Formulations:
Used for serious systemic infections caused by anaerobic bacteria and certain gram-positive aerobes, including:

Severe Skin & Soft Tissue Infections (e.g., abscesses, cellulitis).
Intra-abdominal Infections (often mixed anaerobic/aerobic).
Pelvic Inflammatory Disease (PID).
Bone & Joint Infections.
As an alternative for patients allergic to penicillin.

3. Oral Form (Clindamycin HCl):
For similar systemic infections when oral therapy is appropriate.

Important Warnings & Side Effects

Clostridioides difficile-Associated Diarrhea (CDAD): A major risk. Can cause severe, potentially fatal colitis. Use is reserved for cases where benefits outweigh risks.
Allergy: Contraindicated in patients with hypersensitivity to clindamycin or lincomycin.
Spectrum: Primarily targets anaerobic bacteria and gram-positive cocci (e.g., Staphylococcus aureus, streptococci). NOT effective against gram-negative bacilli.
Prescription Only: Requires medical supervision.

Key Summary Table

Feature	Description
What it is	A soluble prodrug of the antibiotic clindamycin.
Main Mechanism	Inhibits bacterial protein synthesis (bacteriostatic).
Topical Uses	Acne vulgaris, bacterial vaginosis, minor skin infections.
Systemic (IV/IM/Oral) Uses	Serious anaerobic & gram-positive infections (skin, abdomen, bone, pelvis).
Critical Warning	High risk of causing C. difficile colitis (severe diarrhea).
Availability	Prescription-only, in topical (gel, lotion, cream), vaginal, and injectable forms.

Disclaimer: This information is for educational purposes. Clindamycin is a potent antibiotic with significant risks and must be used only under the direction of a healthcare professional.