The mode of action of dihydroartemisinin mainly interferes with the epimembrane-mitochondrial function of the malaria parasite. Through its internal peroxide (dioxygen) bridge, mediated by free iron produced by hemoglobin breakdown, the production of unstable organic radicals and/or other electrophilic intermediaries is then covalent adducts with the proteins of the malaria parasite, causing the malaria parasite to die. Ingestion of tritium-labeled isoleucine by Plasmodium falciparum cultured in vitro has also suggested that its initiation of action may be inhibition of protozoal protein synthesis.
Dihydroartemisinin is an artemisinin derivative that has a powerful and rapid killing effect on the red internal stage of malaria parasite, and can quickly control clinical onset and symptoms. It has the same effect against chloroquine and anti-piperaquine falciparum malaria.
|Appearance||Colorless needle crystal||Conform|
|Loss on drying||≤0.5%||0.35%|
|Residue on ignition||≤0.1%||0.04%|
|Assay(on a dry basis)||98% - 102%||98.4%|
|Appearance:||Colorless needle crystal|
|Purity:||98% - 102%|
|Package details:||1kg/foil bag;25kg/drum|
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