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Guaifenesin is suitable for phlegmatic cough chronic bronchitis, bronchiectasis and other conditions.
Guaifenesin can stimulate the gastric mucosa, reflexively cause an increase in bronchial mucosal gland secretion, reduce the viscosity of sputum, make mucus easy to cough up, suitable for the treatment of sputum is not easy to cough up. Guaifenesin has disinfectant and antiseptic effect, can reduce the foul odor of sputum, but also has antitussive, antispasmodic, anticonvulsant effects, for chronic bronchitis of multi-sputum cough, lung abscess, bronchiectasis and secondary asthma, mostly combined with other antitussive asthmatic drugs.
Items | Specifications | Results |
Appearance | White crystalline powder | White crystalline powder |
Identification | Infrared Absorption:Concordant with the RS spectrum | Concordant with the RS spectrum |
Ultraviolet Absorption: Concordant with the RS spectrum | Concordant with the RS spectrum | |
Assay(on the dried basis) | 98.0~102.0% | 99.5% |
Organic Impurities | Guaifenesin β-isomer≤1.5% | 0.13% |
Guaiacol ≤0.03% | ＜0.01% | |
Other individual impurity | Bisether ≤0.5% | ＜0.01% |
1,3-bis(2-methoxyphenoxy)propan-2-ol ≤0.10% | ＜0.01% | |
Any individual unspecified impurity ≤0.10% | ＜0.01% | |
Total impurities (excluding β-isomer and Guaiacol) ≤1.0% | ＜0.01% | |
Loss on drying | ≤0.5% | 0.02% |
Residual solvent(Ethanol) | ≤0.5% | ＜0.02% |
Conclusion | The product conforms to the above specifications. | |
| Product parameters | |
| Cas number: | 93-14-1 |
| Appearance: | White crystalline powder |
| Purity: | 98~102% |
| Package details: | 25kg/drum |
| Brand: | Fortunachem |
Guaifenesin is a medication classified as an expectorant. It is one of the most common active ingredients in over-the-counter (OTC) cough, cold, and flu remedies. Its primary function is to help loosen and thin mucus (phlegm) in the airways, making it easier to cough up and clear from the lungs and throat.
Secretory Stimulation & Mucus Thinning: Guaifenesin works by increasing the volume and reducing the viscosity (thickness and stickiness) of respiratory tract secretions. It does this by:
Stimulating glands in the respiratory tract to produce more fluid (serous secretions).
Breaking down the structure of the mucoproteins in the phlegm itself.
This action helps transform a dry, hacking, and unproductive cough into a more productive ("wet" or "chesty") cough, which is more effective at clearing congestion and easing chest discomfort.
Symptomatic Relief of Chest Congestion: This is its FDA-approved and most common use. It is indicated for treating symptoms associated with:
The common cold
Upper respiratory infections (like bronchitis)
Influenza (flu)
Allergies that cause chest congestion
Other conditions where thick, hard-to-cough-up mucus is a problem.
Off-Label / Investigational Use:
Fibromyalgia: Some alternative medicine practitioners (notably following the "Dr. St. Amand protocol") use very high doses of guaifenesin in an attempt to reverse phosphate buildup in cells. This use is highly controversial and not supported by mainstream medical science or the FDA. Clinical trials have not proven its effectiveness for fibromyalgia.
Forms: Available as tablets, capsules, extended-release tablets, and liquid syrups (often formulated for adults or children).
Standalone Products: Often sold as just "guaifenesin" or under brands like Mucinex® (notably in extended-release form).
Combination Products: Frequently combined with other ingredients in multi-symptom cold formulas, such as:
With Cough Suppressants: e.g., Robitussin DM® (guaifenesin + dextromethorphan).
With Decongestants: e.g., Mucinex D® (guaifenesin + pseudoephedrine).
With Analgesics/Fever Reducers: e.g., Tylenol Cold + Mucus® (guaifenesin + acetaminophen).
With Antihistamines: For allergy-related congestion.
Common Side Effects: Generally well-tolerated. Mild side effects can include:
Nausea or upset stomach
Vomiting
Dizziness
Headache
Skin rash
Important Instructions:
Hydration is Crucial: Drinking plenty of water or fluids while taking guaifenesin significantly enhances its effectiveness in thinning mucus.
Not a Cough Suppressant: It does not stop you from coughing. Its goal is to make coughing more productive. Do not use it with a prescription cough suppressant unless directed by a doctor.
Dosage: Follow package or doctor instructions. Do not exceed recommended doses.
Who Should Consult a Doctor First:
Individuals with chronic cough due to smoking, asthma, emphysema, or if cough is accompanied by high fever, rash, or persistent headache.
Pregnant or breastfeeding women.
Children under 4 years old (per FDA guidelines; always check product labeling and consult a pediatrician).
Persistent Symptoms: If cough lasts more than 7 days, recurs, or is accompanied by fever that lasts more than 3 days, seek medical advice, as these could be signs of a more serious condition (e.g., pneumonia).
Guaifenesin is a widely used OTC expectorant that helps relieve chest congestion by thinning and loosening mucus in the airways. Its primary and proven use is for managing productive cough symptoms associated with colds, flu, and respiratory infections. It is most effective when taken with adequate fluid intake. While it has a controversial off-label use for fibromyalgia, this application lacks robust scientific support. It is available both as a single-ingredient product and in numerous multi-symptom cold and flu formulations.
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
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