Name: China Factory Supply High Quality Naproxen Sodium CAS 26159-34-2
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Naproxen Sodium CAS 26159-34-2

Items	Specification	Result
Appearance	White to off-white crystalline powder	Conforms
Assay	≥99%	99.9%
Loss on drying	≤1.0%	0.11%
Related substance	Any single impurity≤0.5% Total impurities≤2.0%	Conforms Conforms
Heavy metals	≤20ppm	<20ppm

Parameters of Naproxen Sodium CAS 26159-34-2

Product parameters
Cas number:	26159-34-2
Appearance:	White to off-white crystalline powder
Purity:	99%min
Package details:	25kg/drum
Brand:	Fortunachem

Naproxen Sodium - Definition & Core Information

Naproxen Sodium (CAS No.: 26159-34-2) is the sodium salt form of naproxen, a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class. Its molecular formula is C₁₄H₁₃NaO₃, molecular weight 252.24 g/mol. It appears as a white to off-white crystalline powder, highly soluble in water (unlike naproxen free acid, which is poorly soluble), and stable under normal storage conditions (sealed, dry, 20–25°C, protected from light).

Key Mechanisms of Action

Naproxen sodium exerts its effects by non-selectively inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which blocks the synthesis of prostaglandins—mediators of pain, inflammation, and fever. Its core actions include:

Anti-inflammatory: Reduces tissue inflammation by inhibiting prostaglandin production at the site of injury/infection.
Analgesic: Relieves mild to moderate pain by blocking pain signaling pathways.
Antipyretic: Lowers fever by acting on the hypothalamic thermoregulatory center.

Main Uses

1. Pain Management (Primary Indication)

Mild to moderate acute pain: Headaches (including migraines), dental pain, menstrual cramps (dysmenorrhea), musculoskeletal pain (e.g., back pain, sprains, strains, osteoarthritis/joint pain), post-operative pain (short-term use).
Chronic pain: Long-term management of pain associated with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other inflammatory arthropathies (to reduce pain, stiffness, and swelling).

2. Inflammation Reduction

Treatment of inflammatory conditions: Rheumatoid arthritis, juvenile rheumatoid arthritis (for children ≥2 years old, under medical supervision), ankylosing spondylitis, gouty arthritis (acute attacks, to reduce inflammation and pain).
Soft tissue inflammatory disorders: Bursitis, tendonitis, tenosynovitis.

3. Fever Reduction

Management of fever associated with infections (e.g., viral/bacterial infections) or other causes (e.g., post-vaccination fever), when fever is persistent or accompanied by discomfort.

4. Other Clinical Uses

Off-label use: Short-term relief of pain from tendinitis/bursitis, and adjunctive management of migraine (in combination with antiemetics for severe migraines).

Important Notes

Contraindications: Hypersensitivity to naproxen, other NSAIDs, or aspirin (risk of cross-reactivity); history of asthma, urticaria, or allergic reactions triggered by NSAIDs/aspirin; active peptic ulcer disease; severe renal/hepatic impairment; third-trimester pregnancy (may cause fetal cardiovascular/renal adverse effects).
Adverse effects: Common gastrointestinal symptoms (nausea, dyspepsia, abdominal pain; long-term use increases risk of GI ulcers/bleeding); rare but serious risks (cardiovascular thrombotic events, renal dysfunction, hepatotoxicity, allergic reactions).
Drug interactions: Avoid concurrent use with other NSAIDs/aspirin (increased GI/cardiovascular risk); adjust dosage when combined with anticoagulants (e.g., warfarin) or diuretics (reduced diuretic efficacy, increased renal risk); caution with lithium (elevated lithium levels) and methotrexate (increased methotrexate toxicity).
Dosage considerations: For acute pain/fever, short-term use (≤10 days for pain, ≤3 days for fever) at the lowest effective dose; long-term use requires regular medical monitoring.