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(S)-(+)-Ketoprofen is the biologically active enantiomer of the NSAID ketoprofen. It is a potent inhibitor of cyclooxygenase (COX) enzymes, providing anti-inflammatory, analgesic, and antipyretic effects.
Unlike the racemic mixture (which contains both (S)-(+)- and (R)-(−)-forms), this single enantiomer offers enhanced potency and a faster onset of action. It is marketed under names such as Dexketoprofen and is commonly used for acute pain management, such as musculoskeletal pain, dental pain, or postoperative discomfort, often with improved tolerability.
Items | Technical index |
Product name | (S)-(+)-Ketoprofen |
CAS NO. | 22161-81-5 |
Molecular formula | C16H14O3 |
Molecular weight | 254.28 |
Appearance | White crystalline powder |
Purity | 99%min |
Product parameters | |
Cas number: | 22161-81-5 |
Appearance: | White crystalline powder |
Purity: | 99%min |
Package details: | 1kg/foil bag; 25kg/drum |
Brand: | Fortunachem |
(S)-(+)-Ketoprofen is the biologically active enantiomer of the common nonsteroidal anti-inflammatory drug (NSAID) Ketoprofen. Like other NSAIDs, it works primarily by inhibiting the cyclooxygenase (COX) enzymes, which are involved in producing prostaglandins that cause inflammation, pain, and fever.
The “(S)-(+)” designation indicates its specific three-dimensional chiral structure—this version is responsible for most of the anti-inflammatory and analgesic effects. The opposite enantiomer, (R)-(-)-Ketoprofen, is largely inactive as a COX inhibitor but may contribute to other effects or be converted in vivo.
(S)-(+)-Ketoprofen is often studied and used in purified form to enhance potency and reduce dosage compared to the racemic mixture (which contains both enantiomers). It is available in some markets as a single-enantiomer drug under names such as Dexketoprofen, offering faster onset and potentially improved side-effect profiles.
Melting point:75-78 °C(lit.)
Boiling point:431.3ºC at 760 mmHg
Density:1.198 g/cm3
Flashing point: 228.8ºC
Application:As a non steroidal anti-inflammatory drug, it has anti-inflammatory, analgesic and antipyretic effects
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