Name: China Factory Supply High Quality Best Price Metronidazole CAS 443-48-1
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Metronidazole CAS 443-48-1

Items	Requirements	Results
Appearance	White or yellowish crystalline powder	Complies
Loss on drying	≤0.5%	0.20%
Residue on ignition	≤0.1%	0.05%
Heavy Metal	≤50ppm	＜50ppm
Assay	99.0%～101.0%	100.0%

Parameters of Metronidazole CAS 443-48-1

Product parameters
Cas number:	443-48-1
Appearance:	White or yellowish crystalline powder
Purity:	99%～101%
Package details:	25kg/drum
Brand:	Fortunachem

Metronidazole is a prescription medication classified as both an antibiotic and an antiprotozoal agent. It's widely used to treat infections caused by certain types of bacteria and parasites that thrive in low-oxygen (anaerobic) environments.

Here's a breakdown of its key aspects:

Mechanism of Action:

Once inside the microbial cell, it gets chemically activated.
The activated form damages the DNA of the bacteria or parasite.
This DNA damage prevents the microorganism from repairing itself or replicating, ultimately killing it.
Common Uses (Indications): Metronidazole is effective against:

Trichomoniasis (a sexually transmitted infection)
Amebiasis (intestinal and liver infections caused by Entamoeba histolytica)
Giardiasis (intestinal infection caused by Giardia lamblia)

Intra-abdominal infections (e.g., peritonitis, abscesses)
Gynecological infections (e.g., pelvic inflammatory disease, endometritis, vaginal infections like bacterial vaginosis)
Skin and soft tissue infections
Bone and joint infections
Central nervous system infections (e.g., brain abscess)
Lower respiratory tract infections (e.g., lung abscess, empyema)
Endocarditis (infection of the heart lining)
Septicemia (bloodstream infection)

Anaerobic Bacterial Infections:
Protozoal Infections:
Helicobacter pylori Eradication: Used in combination with other antibiotics to treat stomach/duodenal ulcers caused by H. pylori.
Surgical Prophylaxis: Prevent infections before certain surgeries (especially colorectal, gynecological).
Inflammatory Conditions: Sometimes used for antibiotic-associated colitis (like C. difficile infection - though other agents are often preferred now) and rosacea (topical form).
Available Forms:

Oral tablets and capsules
Intravenous (IV) solution (for serious infections or when oral intake isn't possible)
Topical gel, cream, or lotion (primarily for rosacea and bacterial vaginosis)
Vaginal gel (for bacterial vaginosis)
Important Considerations & Side Effects:

Generally avoided during the first trimester of pregnancy unless absolutely necessary. Can be used later in pregnancy for specific infections (e.g., trichomoniasis, bacterial vaginosis) after weighing risks/benefits.
It passes into breast milk and can give milk a bitter taste. Consult your doctor; sometimes breastfeeding needs to be interrupted during treatment.

Neurological: Numbness, tingling, pain, or weakness in hands/feet (peripheral neuropathy - can be irreversible), seizures, confusion, dizziness/vertigo.
Allergic reactions: Rash, itching, hives, swelling (face/tongue/throat), severe dizziness, trouble breathing.
Severe abdominal pain, persistent nausea/vomiting.
Signs of liver problems: Yellowing eyes/skin, dark urine, persistent nausea/vomiting, severe stomach/abdominal pain.

Nausea (most common), vomiting, diarrhea, stomach upset/cramps, loss of appetite, metallic taste in the mouth.
Headache, dizziness.
Darkening of urine (harmless, due to a metabolite).

Alcohol Interaction (CRITICAL): Avoid ALL alcohol (including beverages, mouthwash, cough syrup, food cooked with alcohol) while taking metronidazole and for at least 48-72 hours after finishing the course. Combining them can cause a severe reaction (disulfiram-like reaction) with symptoms like intense nausea, vomiting, flushing, headache, rapid heartbeat, and abdominal cramps.
Common Side Effects:
Less Common but Serious Side Effects (Require immediate medical attention):
Pregnancy & Breastfeeding:
Drug Interactions: Can interact with several medications, including:

Blood thinners (e.g., warfarin - increases risk of bleeding).
Lithium (increases lithium levels and risk of toxicity).
Disulfiram (used for alcoholism - increases risk of psychiatric reactions).
Some seizure medications (phenytoin, phenobarbital).
Busulfan (chemotherapy drug).
Always tell your doctor and pharmacist about ALL medications and supplements you are taking.
Resistance: Like all antibiotics, bacterial resistance to metronidazole is a growing concern. It should only be used when necessary and prescribed appropriately.

Key Takeaways:

Metronidazole is a powerful antibiotic/antiprotozoal for anaerobic bacteria and certain parasites.
ABSOLUTELY AVOID ALCOHOL during treatment and for several days afterward.
Common side effects include nausea and a metallic taste; report serious side effects immediately.
Inform your healthcare provider about all other medications and medical conditions.
Always take the full prescribed course, even if you feel better, to ensure the infection is eradicated and prevent resistance.
Follow your doctor's instructions and pharmacist's advice carefully.

Important: This information is for general knowledge only. Always consult your doctor or pharmacist for personalized medical advice regarding metronidazole, including its use, dosage, potential side effects, and interactions specific to your situation.