Name: China Supplier High Quality Chlorpheniramine Maleate CAS 113-92-8 with good service
Brand: Wuhan Fortuna Chemical Co., Ltd.

Specifications of Chlorpheniramine Maleate CAS 113-92-8

Item	Specifications	Results
Appearance	White or almost white crystalline powder	Conform
Heavy Metal	≤20ppm	Conform
Melting point	130.0 – 135.0℃	131.5℃
PH	4.0 – 5.0	4.83%
Sulphate ash	≤0.1%	0.06%
Loss on drying	≤0.5%	0.14%
Assay	98.0% - 101.0%	99.51%

Parameters of Chlorpheniramine Maleate CAS 113-92-8

Product parameters
Cas number:	113-92-8
Appearance:	White or almost white crystalline powder
Purity:	98.0% - 101.0%
Package details:	25kg/drum
Brand:	Fortunachem

Chlorphenamine Maleate (often just called Chlorphenamine) is a common, first-generation antihistamine medication. It's primarily used to relieve the symptoms of allergies, such as hay fever, hives, and the common cold.

Its most notable characteristic is that it is sedating, meaning it often causes drowsiness.

Detailed Breakdown

1. What It Is and How It Works

Drug Class: Alkylamine (first-generation) antihistamine.
Mechanism of Action: It works by blocking the effects of histamine, a natural substance your body releases during an allergic reaction. Histamine is responsible for causing symptoms like sneezing, itching, watery eyes, and a runny nose. By blocking the histamine receptors (specifically the H1-receptors), Chlorphenamine stops these symptoms.
The "Maleate" Part: This is the salt form of the drug (Chlorphenamine + Maleic Acid). It is used to make the compound more stable and soluble, which helps in manufacturing it into tablets or liquids. The active part of the medicine is the Chlorphenamine itself.

2. Common Uses

Chlorphenamine is used to treat:

Allergic Rhinitis: Hay fever symptoms like sneezing, runny nose, and itchy throat.
Allergic Conjunctivitis: Itchy, watery eyes.
Urticaria: Hives and skin rashes.
Common Cold: It helps dry up a runny nose and reduce sneezing (though it doesn't cure the cold virus).
Allergic Reactions: It is sometimes used to manage mild allergic reactions to foods, insect stings, or other triggers.
Anaphylaxis: It can be used as an adjunct (additional) treatment for severe allergic reactions (anaphylaxis), but it is not a replacement for epinephrine, which is the first-line, life-saving treatment.

3. Common Brand Names and Forms

Chlorphenamine is available both as a prescription and over-the-counter (OTC) in many countries.

Brand Names: Piriton, Allerief, Haymine, Chlor-Trimeton.
Forms:

Tablets
Syrup/Liquid (for children or those who have difficulty swallowing pills)
Injectable Solution (for use in hospitals for severe cases)

4. Key Side Effects

Because it is a first-generation antihistamine, it readily crosses the blood-brain barrier, leading to significant effects on the central nervous system.

Very Common:

Drowsiness / Sedation (This is the most well-known side effect)
Dizziness
Dry mouth, nose, and throat
Blurred vision

Less Common:

Headache
Upset stomach
Loss of appetite
Coordination problems

Important Note: Due to the sedating effects, you should not drive or operate heavy machinery until you know how this medicine affects you.

5. Important Warnings and Interactions

Alcohol: Do NOT consume alcohol while taking Chlorphenamine, as it can severely increase drowsiness and dizziness.
Other CNS Depressants: It can have an additive effect with other drugs that cause drowsiness, such as:

Sleeping pills (e.g., zolpidem)
Anxiety medications (e.g., benzodiazepines like diazepam)
Certain pain medications (e.g., opioids like codeine)

Medical Conditions: Use with caution if you have:

Glaucoma
An enlarged prostate or difficulty urinating
Epilepsy
High blood pressure
Liver or kidney disease

Pregnancy and Breastfeeding: It is generally not recommended unless specifically advised by a doctor.

Comparison with Modern Antihistamines

Feature	Chlorphenamine (First-Gen)	Modern Antihistamines (e.g., Loratadine, Cetirizine, Fexofenadine)
Drowsiness	High (Significantly sedating)	Low to None (Non-sedating or less sedating)
Duration	Shorter-acting (typically 4-6 hours)	Longer-acting (typically 12-24 hours)
Use	Good for nighttime relief (due to drowsiness)	Better for daytime use (no drowsiness)
Other Effects	More anticholinergic side effects (dry mouth, etc.)	Fewer anticholinergic side effects

Summary

Chlorphenamine Maleate is an effective and inexpensive antihistamine that has been used for decades. While it is very good at relieving allergy symptoms, its main drawback is the significant drowsiness it causes. For this reason, newer, non-sedating antihistamines are often preferred for daytime use. However, it remains a popular choice for providing relief, especially at night.

Disclaimer: This information is for educational purposes only and is not medical advice. Always consult with a doctor or pharmacist before taking any new medication to ensure it is safe and appropriate for you.