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Camostat mesilate is an orally administered protease inhibitor drug. Its primary approved use is treating chronic pancreatitis and related pain, as it inhibits the digestive enzyme trypsin, reducing pancreatic inflammation. It has gained significant research interest for its antiviral potential. By inhibiting the host enzyme TMPRSS2, it can block the spike protein priming required for viral entry of pathogens like SARS-CoV-2 and influenza. While clinical results for COVID-19 have been mixed, it remains a key compound for studying viral infection mechanisms. It is marketed under brands like Foipan®.
Items | Specifications | Results |
Appearance | Off-white powder | |
Purity | ≥99.5% | 99.92% |
Identification | The retention time of the test product was consistent with that of the control product in the HPLC. | Conforms |
Loss on drying | ≤2.0% | 0.14% |
Maximum single impurity | ≤0.1% | 0.07% |
Residue on ignition | 0 | |
Conclusion | This product complies with the specifications. | |
| Product parameters | |
| Cas number: | 59721-29-8 |
| Appearance: | White to off-white powder |
| Purity: | 99.5%min |
| Package details: | 100g/bottle; 1kg/foil bag |
| Brand: | Fortunachem |
Camostat mesilate (or camostat mesylate) is a synthetic, orally administered protease inhibitor drug. In simpler terms, it works by blocking the activity of specific enzymes that cut proteins, a process known as proteolysis.
Its primary mechanism is inhibiting key serine proteases, most notably:
Transmembrane protease, serine 2 (TMPRSS2): This enzyme is present on the surface of cells in the respiratory tract, pancreas, and other organs. It plays a crucial role in priming the spike protein of certain viruses, like SARS-CoV-2 (the virus that causes COVID-19) and influenza, allowing the virus to fuse with and enter human cells. By blocking TMPRSS2, camostat mesilate can potentially prevent viral entry.
Trypsin: It is a powerful digestive enzyme produced by the pancreas.
Treatment of Chronic Pancreatitis and Pancreatic Pain: This is its most well-established and approved use (particularly in Japan and South Korea). By inhibiting trypsin, it reduces the auto-digestive processes and inflammation in the pancreas, which helps alleviate pain and other symptoms.
Investigated for Viral Infections: Due to its inhibition of TMPRSS2, it has been extensively studied as a repurposed drug for COVID-19. Early in vitro (lab-based) studies showed promise in blocking SARS-CoV-2 entry, but clinical trial results in humans have been mixed, showing modest or inconclusive benefits. Research for other TMPRSS2-dependent viruses is ongoing.
Brand Name: Foipan® (in Japan).
Prodrug: It is administered as an inactive prodrug. After ingestion, it is metabolized in the body into its active form, 4-(4-guanidinobenzoyloxy)phenylacetic acid (GBPA).
In summary, Camostat mesilate is a repurposed protease inhibitor drug primarily used for pancreatic inflammation, with significant research interest as a potential antiviral agent for respiratory viruses like SARS-CoV-2.
Used in the relief of acute symptoms of chronic pancreatitis.
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